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Non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 450.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.02 mM||111.04 mL||555.21 mL||1110.42 mL|
|0.1 mM||22.21 mL||111.04 mL||222.08 mL|
|0.2 mM||11.1 mL||55.52 mL||111.04 mL|
|1 mM||2.22 mL||11.1 mL||22.21 mL|
References are publications that support the biological activity of the product.
Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440
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Keywords: BPIPP, BPIPP supplier, Non-competitive, GC, inhibitors, inhibits, Guanylyl, Cyclases, Cyclase, Adenylyl, 3635, Tocris Bioscience
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