BMX-IN-1

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Cat.No. 5123 - BMX-IN-1 | C29H24N4O4S | CAS No. 1431525-23-3
Description: Potent and irreversible BMX inhibitor
Chemical Name: N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.

Technical Data

M. Wt 524.59
Formula C29H24N4O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1431525-23-3
PubChem ID 71576693
InChI Key SFMJNHNUOVADRW-UHFFFAOYSA-N
Smiles CC(C=C5)=C(NC(C=C)=O)C=C5N(C2=C(C=C3)C=NC1=CC=C(C4=CC=C(NS(=O)(C)=O)C=C4)C=C12)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.52 1 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 524.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.53 mL 19.06 mL
5 mM 0.38 mL 1.91 mL 3.81 mL
10 mM 0.19 mL 0.95 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Liu et al (2013) Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem.Biol. 8 1423 PMID: 23594111

Li et al (2017) BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. Oncotarget. 8 49238 PMID: 28514765


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Keywords: BMX-IN-1, BMX-IN-1 supplier, BMX, inhibitors, inhibits, nonreceptor, tyrosine, kinase, potent, irreversible, selective, Other, Kinases, 5123, Tocris Bioscience

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