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Potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.
Sold under license from Dana-Farber Cancer Institute.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||0.52||1 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 524.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.01 mM||190.63 mL||953.13 mL||1906.25 mL|
|0.05 mM||38.13 mL||190.63 mL||381.25 mL|
|0.1 mM||19.06 mL||95.31 mL||190.63 mL|
|0.5 mM||3.81 mL||19.06 mL||38.13 mL|
References are publications that support the biological activity of the product.
Liu et al (2013) Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem.Biol. 8 1423 PMID: 23594111
Li et al (2017) BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. Oncotarget. 8 49238 PMID: 28514765
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Keywords: BMX-IN-1, BMX-IN-1 supplier, BMX, inhibitors, inhibits, nonreceptor, tyrosine, kinase, potent, irreversible, selective, Other, Kinases, 5123, Tocris Bioscience
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