Potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.
Sold under license from Dana-Farber Cancer Institute.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||0.52||1mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 524.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.91 mL||9.53 mL||19.06 mL|
|5 mM||0.38 mL||1.91 mL||3.81 mL|
|10 mM||0.19 mL||0.95 mL||1.91 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References are publications that support the products' biological activity.
Liu et al (2013) Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem.Biol. 8 1423 PMID: 23594111
Li et al (2017) BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. Oncotarget. 8 49238 PMID: 28514765
If you know of a relevant reference for BMX-IN-1, please let us know.
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Keywords: BMX-IN-1, supplier, BMX, inhibitors, inhibits, nonreceptor, tyrosine, kinase, potent, irreversible, selective, Other, Kinases, Other, Kinases, Tocris Bioscience
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