BMS 509744

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Cat.No. 5009 - BMS 509744 | C32H41N5O4S2 | CAS No. 439575-02-7
Description: Potent and selective ITK inhibitor
Chemical Name: N-[5-[[5-[(4-Acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]methyl]benzamide
Purity: ≥97% (HPLC)
Citations (1)
Literature (3)

Biological Activity for BMS 509744

BMS 509744 is a potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitor (IC50 = 19 nM). Displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. Reduces HIV infection of primary CD4+ T cells and attenuates the establishment of HIV infection in vitro. Reduces T cell proliferation and IL-2 production in vitro. Reduces lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.

Compound Libraries for BMS 509744

BMS 509744 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BMS 509744

M. Wt 623.83
Formula C32H41N5O4S2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 439575-02-7
PubChem ID 11467730
Smiles COC1=CC(C)=C(SC3=CN=C(NC(C4=CC=C(CNC(C)C(C)(C)C)C=C4)=O)S3)C=C1C(N2CCN(C(C)=O)CC2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 509744

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 62.38 100
DMSO 31.19 50

Preparing Stock Solutions for BMS 509744

The following data is based on the product molecular weight 623.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.6 mL 8.02 mL 16.03 mL
5 mM 0.32 mL 1.6 mL 3.21 mL
10 mM 0.16 mL 0.8 mL 1.6 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets for BMS 509744

Certificate of Analysis / Product Datasheet
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References for BMS 509744

References are publications that support the biological activity of the product.

Kutach et al (2010) Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation. Chem Biol Drug Des. 76 154 PMID: 20545945

Das et al (2006) Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg.Med.Chem.Lett. 16 3706 PMID: 16682193

Readinger et al (2008) Selective targeting of ITK blocks multiple steps of HIV replication. Proc.Natl.Acad.Sci.U.S.A. 105 6684 PMID: 18443296

If you know of a relevant reference for BMS 509744, please let us know.

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Keywords: BMS 509744, BMS 509744 supplier, BMS509744, lung, inflammation, allergy, asthma, inducible, T, cell, kinase, emt, tsk, HIV, potent, selective, ITK, inhibitors, inhibits, Il2, 5009, Tocris Bioscience

1 Citation for BMS 509744

Citations are publications that use Tocris products. Selected citations for BMS 509744 include:

Mamand et al (2018) Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep 8 14216 PMID: 30242208

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Literature in this Area

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