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Bis-ANS

Cat. No. 5908 Submit a Review Datasheet / COA / SDS
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Cat.No. 5908 - Bis-ANS | C32H22K2N2O6S2 | CAS No. 65664-81-5
Description: Fluorescent probe for nonpolar cavities in proteins; used to detect Aβ fibres
Chemical Name: 4,4'-Bis(phenylamino)-[1,1'-binaphthalene]-5,5'-disulfonic acid dipotassium salt
Purity: ≥97% (HPLC)
Datasheet
Citations
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Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Fluorescent probe for nonpolar cavities in proteins. Used to detect Aβ fibre (Kd = ~80 nM); exhibits distinct fluorescent profiles for fibres and oligomers. Fluoresces in hydrophobic environments, negligible fluorescence in water solutions. Excitation\emission λ ~ 355\520 nm at pH 7.4.

Technical Data

M. Wt 672.85
Formula C32H22K2N2O6S2
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 65664-81-5
PubChem ID 16213473
InChI Key VWLWTJHKQHRTNC-UHFFFAOYSA-L
Smiles O=S(C1=CC=CC2=C1C(NC3=CC=CC=C3)=CC=C2C4=CC=C(NC5=CC=CC=C5)C6=C(S(=O)([O-])=O)C=CC=C46)([O-])=O.[K+].[K+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.28 100
water 13.46 20

Preparing Stock Solutions

The following data is based on the product molecular weight 672.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.49 mL 7.43 mL 14.86 mL
5 mM 0.3 mL 1.49 mL 2.97 mL
10 mM 0.15 mL 0.74 mL 1.49 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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References

References are publications that support the biological activity of the product.

Rosen et al (1969) Dimer formation from 1-amino-8-naphthalenesulfonate catalyzed by bovine serum albumin. A new fluorescent molecule with exceptional binding properties. Biochemistry 8 3915 PMID: 5388144

Younan et al (2015) A comparison of three fluorophores for the detection of amyloid fibers and prefibrillar oligomeric assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid). Biochemistry 54 4297 PMID: 26087242

If you know of a relevant reference for Bis-ANS, please let us know.

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Citations for Bis-ANS

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