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Cat.No. 5372 - Bioymifi | C22H12BrN3O4S | CAS No. 1420071-30-2
Description: DR5 (TRAIL receptor) agonist; induces apoptosis
Chemical Name: 5-[5-[[(5Z)-3-(4-Bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-1H-isoindole-1,3(2H)-dione
Purity: ≥97% (HPLC)
Literature (3)

Biological Activity for Bioymifi

Bioymifi is a DR5 (TRAIL receptor) agonist. Directly binds extracellular domain of DR5 (Kd = 1.2 μM) and induces the formation of DR5 aggregates. Induces apoptosis of glioblastoma cells.

Technical Data for Bioymifi

M. Wt 494.32
Formula C22H12BrN3O4S
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1420071-30-2
PubChem ID 70678419
Smiles BrC1=CC=C(N3C(/C(SC3=N)=C/C2=CC=C(C4=CC=C(C(NC5=O)=O)C5=C4)O2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bioymifi

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 0.49 1 with gentle warming

Preparing Stock Solutions for Bioymifi

The following data is based on the product molecular weight 494.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 202.3 mL 1011.49 mL 2022.98 mL
0.05 mM 40.46 mL 202.3 mL 404.6 mL
0.1 mM 20.23 mL 101.15 mL 202.3 mL
0.5 mM 4.05 mL 20.23 mL 40.46 mL

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References for Bioymifi

References are publications that support the biological activity of the product.

Wang et al (2013) Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat.Chem.Biol. 9 84 PMID: 23292651

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Keywords: Bioymifi, Bioymifi supplier, TRAIL, tumor, necrosis, factor-related, apoptosis-inducing, ligand, DR5, TNF, agonists, agonism, Cytokine, Receptors, Apoptosis, Inducers, 5372, Tocris Bioscience

Citations for Bioymifi

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