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Cat.No. 5372 - Bioymifi | C22H12BrN3O4S | CAS No. 1420071-30-2
Description: DR5 (TRAIL receptor) agonist; induces apoptosis
Chemical Name: 5-[5-[[(5Z)-3-(4-Bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-1H-isoindole-1,3(2H)-dione
Purity: ≥97% (HPLC)

Biological Activity

DR5 (TRAIL receptor) agonist. Directly binds extracellular domain of DR5 (Kd = 1.2 μM) and induces the formation of DR5 aggregates. Induces apoptosis of glioblastoma cells.

Technical Data

M. Wt 494.32
Formula C22H12BrN3O4S
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1420071-30-2
PubChem ID 70678419
Smiles BrC1=CC=C(N3C(/C(SC3=N)=C/C2=CC=C(C4=CC=C(C(NC5=O)=O)C5=C4)O2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 0.49 1mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 494.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.11 mL 20.23 mL
5 mM 0.4 mL 2.02 mL 4.05 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References are publications that support the products' biological activity.

Wang et al (2013) Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat.Chem.Biol. 9 84 PMID: 23292651

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Keywords: Bioymifi, supplier, TRAIL, tumor, necrosis, factor-related, apoptosis-inducing, ligand, DR5, TNF, agonists, agonism, Cytokine, Receptors, Apoptosis, Inducers, Cytokine, Receptors, Tocris Bioscience

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