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DR5 (TRAIL receptor) agonist. Directly binds extracellular domain of DR5 (Kd = 1.2 μM) and induces the formation of DR5 aggregates. Induces apoptosis of glioblastoma cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||0.49||1 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 494.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.01 mM||202.3 mL||1011.49 mL||2022.98 mL|
|0.05 mM||40.46 mL||202.3 mL||404.6 mL|
|0.1 mM||20.23 mL||101.15 mL||202.3 mL|
|0.5 mM||4.05 mL||20.23 mL||40.46 mL|
References are publications that support the biological activity of the product.
Wang et al (2013) Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat.Chem.Biol. 9 84 PMID: 23292651
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Keywords: Bioymifi, Bioymifi supplier, TRAIL, tumor, necrosis, factor-related, apoptosis-inducing, ligand, DR5, TNF, agonists, agonism, Cytokine, Receptors, Apoptosis, Inducers, 5372, Tocris Bioscience
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.