DR5 (TRAIL receptor) agonist. Directly binds extracellular domain of DR5 (Kd = 1.2 μM) and induces the formation of DR5 aggregates. Induces apoptosis of glioblastoma cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||0.49||1 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 494.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.02 mL||10.11 mL||20.23 mL|
|5 mM||0.4 mL||2.02 mL||4.05 mL|
|10 mM||0.2 mL||1.01 mL||2.02 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References are publications that support the biological activity of the product.
Wang et al (2013) Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat.Chem.Biol. 9 84 PMID: 23292651
If you know of a relevant reference for Bioymifi, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Bioymifi, Bioymifi supplier, TRAIL, tumor, necrosis, factor-related, apoptosis-inducing, ligand, DR5, TNF, agonists, agonism, Cytokine, Receptors, Apoptosis, Inducers, 5372, Tocris Bioscience
Citations for Bioymifi
Citations are publications that use Tocris products.
Currently there are no citations for Bioymifi. Do you know of a great paper that uses Bioymifi from Tocris? Please let us know.
Reviews for Bioymifi
There are currently no reviews for this product. Be the first to review Bioymifi and earn rewards!
Have you used Bioymifi?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.