You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for BCTC
BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.
Compound Libraries for BCTC
Technical Data for BCTC
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BCTC
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BCTC
The following data is based on the product molecular weight 372.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.68 mL||13.41 mL||26.82 mL|
|5 mM||0.54 mL||2.68 mL||5.36 mL|
|10 mM||0.27 mL||1.34 mL||2.68 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for BCTC
References are publications that support the biological activity of the product.
Pomonis et al (2003) N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflamma J.Pharmacol.Exp.Ther. 306 387 PMID: 12721336
Valenzano et al (2003) N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic proper J.Pharmacol.Exp.Ther. 306 377 PMID: 12721338
If you know of a relevant reference for BCTC, please let us know.
View Related Products by Product Action
Keywords: BCTC, BCTC supplier, vanilloid, trpv1, antagonists, transient, receptors, potential, channels, TRPV, 3875, Tocris Bioscience
2 Citations for BCTC
Citations are publications that use Tocris products. Selected citations for BCTC include:
Lars et al (2014) Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest 124 3793-806 PMID: 25083990
Lian et al (2017) Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis. Mol Med Rep 16 1920 PMID: 28627595
Do you know of a great paper that uses BCTC from Tocris? Please let us know.
Reviews for BCTC
There are currently no reviews for this product. Be the first to review BCTC and earn rewards!
Have you used BCTC?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image