BCTC

Pricing Availability   Qty
Description: TRPV1 antagonist
Chemical Name: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for BCTC

BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.

Compound Libraries for BCTC

BCTC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BCTC

M. Wt 372.89
Formula C20H25ClN4O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 393514-24-4
PubChem ID 9929425
InChI Key ROGUAPYLUCHQGK-UHFFFAOYSA-N
Smiles ClC1=CC=CN=C1N2CCN(C(NC3=CC=C(C(C)(C)C)C=C3)=O)CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BCTC

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.29 100
ethanol 14.92 40

Preparing Stock Solutions for BCTC

The following data is based on the product molecular weight 372.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.41 mL 26.82 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

View Related Products by Target

View Related Products by Product Action

View all TRPV Channel Antagonists

Keywords: BCTC, BCTC supplier, vanilloid, trpv1, antagonists, transient, receptors, potential, channels, TRPV, 3875, Tocris Bioscience

1 Citation for BCTC

Citations are publications that use Tocris products. Selected citations for BCTC include:

Lian et al (2017) Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis. Mol Med Rep 16 1920 PMID: 28627595


Do you know of a great paper that uses BCTC from Tocris? Please let us know.

Reviews for BCTC

There are currently no reviews for this product. Be the first to review BCTC and earn rewards!

Have you used BCTC?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain Poster

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.