BAN ORL 24

Discontinued Product

BAN ORL 24 (Cat. No. 3661) has been withdrawn from sale for commercial reasons.
Cat.No. 3661 - BAN ORL 24 | C27H35N3O2.2HCl | CAS No. 1401463-54-4
Description: Potent and selective NOP antagonist
Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Potent and selective NOP receptor antagonist (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.

Compound Libraries

BAN ORL 24 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 506.51
Formula C27H35N3O2.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1401463-54-4
PubChem ID 56840444
InChI Key NEEVITHVDIQNJY-KHZPMNTOSA-N
Smiles O=[C@@]([C@H]2CCCN2CC3=CC=CC=C3)NCCCN1CCC4(OCC5=C4C=CC=C5)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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1 Citation for BAN ORL 24

Citations are publications that use Tocris products. Selected citations for BAN ORL 24 include:

Aatsinki et al (2014) MetF. induces PGC-1α expression and selectively affects hepatic PGC-1α functions. Am J Physiol Cell Physiol 171 2351 PMID: 24428821


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