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Cat.No. 4810 - BAM 7 | C21H19N5O2S | CAS No. 331244-89-4
Description: Selective Bax activator; induces Bax-mediated apoptosis
Chemical Name: 3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]
Purity: ≥99% (HPLC)
Literature (4)
Pathways (1)

Biological Activity for BAM 7

BAM 7 is a Bax activator (EC50 = 3.3 μM); binds at the BH3-binding site. Selective for Bax over other antiapoptotic and proapoptotic proteins. Triggers Bax oligomerization in vitro; induces Bax-mediated apoptosis in mouse embryonic fibroblasts.

Technical Data for BAM 7

M. Wt 405.47
Formula C21H19N5O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 331244-89-4
PubChem ID 5754137
Smiles CC(/C1=N\NC2=C(OCC)C=CC=C2)=NN(C3=NC(C4=CC=CC=C4)=CS3)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAM 7

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.05 10

Preparing Stock Solutions for BAM 7

The following data is based on the product molecular weight 405.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.66 mL 123.31 mL 246.63 mL
0.5 mM 4.93 mL 24.66 mL 49.33 mL
1 mM 2.47 mL 12.33 mL 24.66 mL
5 mM 0.49 mL 2.47 mL 4.93 mL

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References for BAM 7

References are publications that support the biological activity of the product.

Gavathiotis et al (2012) Direct and selective small-molecule activation of proapoptotic BAX. Nat.Chem.Biol. 8 639 PMID: 22634637

If you know of a relevant reference for BAM 7, please let us know.

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Keywords: BAM 7, BAM 7 supplier, BAM7, bax, proapoptotic, apoptosis, activators, BH3, binding, site, inducers, oligomerization, selective, Bcl-2, Family, Apoptosis, Inducers, 4810, Tocris Bioscience

Citations for BAM 7

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Literature in this Area

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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for BAM 7


Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.