BAM 7

Pricing Availability   Qty
Cat.No. 4810 - BAM 7 | C21H19N5O2S | CAS No. 331244-89-4
Description: Selective Bax activator; induces Bax-mediated apoptosis
Chemical Name: 3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Bax activator (EC50 = 3.3 μM); binds at the BH3-binding site. Selective for Bax over other antiapoptotic and proapoptotic proteins. Triggers Bax oligomerization in vitro; induces Bax-mediated apoptosis in mouse embryonic fibroblasts.

Technical Data

M. Wt 405.47
Formula C21H19N5O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 331244-89-4
PubChem ID 5754137
InChI Key KOCVKGYKBLJEPK-LYBHJNIJSA-N
Smiles CC(/C1=N\NC2=C(OCC)C=CC=C2)=NN(C3=NC(C4=CC=CC=C4)=CS3)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.05 10

Preparing Stock Solutions

The following data is based on the product molecular weight 405.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.66 mL 123.31 mL 246.63 mL
0.5 mM 4.93 mL 24.66 mL 49.33 mL
1 mM 2.47 mL 12.33 mL 24.66 mL
5 mM 0.49 mL 2.47 mL 4.93 mL

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References

References are publications that support the biological activity of the product.

Gavathiotis et al (2012) Direct and selective small-molecule activation of proapoptotic BAX. Nat.Chem.Biol. 8 639 PMID: 22634637


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Citations for BAM 7

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for BAM 7

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.