Baicalein

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Cat.No. 1761 - Baicalein | C15H10O5 | CAS No. 491-67-8
Description: 5- and 12-Lipoxygenase inhibitor
Chemical Name: 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation.

Technical Data

M. Wt 270.24
Formula C15H10O5
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 491-67-8
PubChem ID 5281605
InChI Key FXNFHKRTJBSTCS-UHFFFAOYSA-N
Smiles OC1=C(O)C(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.51 50

Preparing Stock Solutions

The following data is based on the product molecular weight 270.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hsu et al (2001) Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 425 165 PMID: 11513834

Nakahata et al (2003) Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 461 1 PMID: 12568909

Sekiya and Okuda (1982) Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 105 1090 PMID: 6807310

Hsieh et al (2007) Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 26 5 PMID: 18039391


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View Related Products by Product Action

View all Lipoxygenase Inhibitors

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3 Citations for Baicalein

Citations are publications that use Tocris products. Selected citations for Baicalein include:

Maskrey et al (2014) 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition. PLoS One 11 33 PMID: 25349537

Potapova et al (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. PLoS One 8 e73929 PMID: 24069252

Gibson et al (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57 746 PMID: 18341994


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