Pricing Availability   Qty
Description: 5- and 12-Lipoxygenase inhibitor
Chemical Name: 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Citations (6)
Literature (2)

Biological Activity for Baicalein

Baicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. Also inhibits erastin-induced ferroptosis.

Technical Data for Baicalein

M. Wt 270.24
Formula C15H10O5
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 491-67-8
PubChem ID 5281605
Smiles OC1=C(O)C(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Baicalein

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 13.51 50

Preparing Stock Solutions for Baicalein

The following data is based on the product molecular weight 270.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.4 mL 37 mL 74.01 mL
2.5 mM 1.48 mL 7.4 mL 14.8 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
25 mM 0.15 mL 0.74 mL 1.48 mL

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Product Datasheets for Baicalein

Certificate of Analysis / Product Datasheet
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References for Baicalein

References are publications that support the biological activity of the product.

Hsu et al (2001) Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 425 165 PMID: 11513834

Nakahata et al (2003) Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 461 1 PMID: 12568909

Sekiya and Okuda (1982) Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 105 1090 PMID: 6807310

Hsieh et al (2007) Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 26 5 PMID: 18039391

Xie et al (2016) Identification of Baicalein as a ferroptosis inhibitor by natural product library screening. Biochem.Biophys.Res.Commun. 473 775 PMID: 27037021

If you know of a relevant reference for Baicalein, please let us know.

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View all Lipoxygenase Inhibitors

Keywords: Baicalein, Baicalein supplier, Induces, G1, G2, cell, cycle, arrest, lipoxygenase, inhibitors, inhibits, 5-Lipoxygenase, platelet, 12-Lipoxygenase, Cell, Cycle, Lipoxygenase, Oxygenases, Oxidases, 5-LOX, 12-LOX, Inhibitors, Ferroptosis, 1761, Tocris Bioscience

6 Citations for Baicalein

Citations are publications that use Tocris products. Selected citations for Baicalein include:

Starowicz et al (2013) Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. PLoS One 8 e60040 PMID: 23573230

Oguh-Olayinka et al (2019) The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res PMID: 30941737

Maskrey et al (2014) 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition. PLoS One 11 33 PMID: 25349537

Mishra et al (2017) Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol 2 17072 PMID: 28504669

Do you know of a great paper that uses Baicalein from Tocris? Please let us know.

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Literature in this Area

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