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Cat.No. 2855 - B2 | C20H17ClN4O3 | CAS No. 115687-05-3
Description: Promotes inclusion formation in Huntington's and Parkinson's diseases
Alternative Names: CPNQ
Chemical Name: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
Purity: ≥98% (HPLC)

Biological Activity

Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

Technical Data

M. Wt 396.83
Formula C20H17ClN4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 115687-05-3
PubChem ID 3953303
Smiles O=C(C4=CC=C(Cl)C=C4)N(CC3)CCN3C1=C(C=CC=N2)C2=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.68 100
ethanol 3.97 10

Preparing Stock Solutions

The following data is based on the product molecular weight 396.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.6 mL 25.2 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References are publications that support the biological activity of the product.

Bodner et al (2006) Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parksinson's diseases. Proc.Natl.Acad.Sci.USA 103 4246

If you know of a relevant reference for B2, please let us know.

Keywords: B2, B2 supplier, Promotes, inclusion, formation, Huntingtons, Parkinsons, parkinson's, diseases, Huntingdons, Neuronal, Metabolism, Huntington's, CPNQ, Miscellaneous, Compounds, 2855, Tocris Bioscience

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