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Non-specific endogenous agonist at the inhibitory glycine receptor. More selective than taurine (Cat. No. 0209). Also distinguishes between GABA transporters (IC50 values are 19, 58, 110, 1320 and 5690 μM for rGAT-2, hGAT-3, rGAT-3, hBGT-3 and hGAT-1 respectively). Also MRGPRD agonist.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 100 mM in water|
References are publications that support the biological activity of the product.
Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497
Saitoh et al (1994) A novel antagonist, phenylbenzene ω-phosphono-α-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br.J.Pharmacol. 113 165 PMID: 7812607
Schieden and Betz (1995) Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol.Pharmacol. 48 919 PMID: 7476923
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
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Keywords: beta-Alanine, beta-Alanine supplier, Endogenous, glycine, agonists, selective, Taurine, GABA, uptake, inhibitors, inhibits, GAT-2, -3, receptor, GlyR, Glycine, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, beta-alanine, β-alanine, MRGPRD, agonism, mas-related, g, protein-coupled, Mas-related, G, Protein-Coupled, 0206, Tocris Bioscience
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Glycine receptors of Alpha1+Beta subunit composition were expressed in HEK cells and then tested for functionality by beta-alanine application. As predicted, beta-alanine (1 mM) evoked a clear response, then fully blocked by strychnine (1 microM). Figure: response evoked by beta-alanine in a HEK-293 cell expressing glycine receptors.
Easily soluble compound, stable in water solution. Can be stored in fridge for months.
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