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Description: Reagent for modifying RNA via 2'-OH sulfonylation; for SHAPE MaP experiments
Chemical Name: 5-((1H-1,2,4-Triazol-1-yl)sulfonyl)-2-(3-(2-(2-azidoethoxy)ethoxy)prop-1-yn-1-yl)pyridine
Purity: ≥95% (HPLC)
Literature (3)

Biological Activity for AzP3S

AzP3S is a pyridine sulfonyl triazole for modifying RNA via RNA 2'-OH sulfonylation. AzP3S can be used for RNA SHAPE-MaP experiments in cell lines and bacteria. Allows fluorescent labeling of RNA using Cu-free click chemistry. Stable in aqueous media and in storage at room temperature, can be purified with silica gel chromatography.

Technical Data for AzP3S

M. Wt 377.38
Formula C14H15N7O4S
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=S(C1=CC=C(N=C1)C#CCOCCOCCN=[N+]=[N-])(N2C=NC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AzP3S

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.74 100

Preparing Stock Solutions for AzP3S

The following data is based on the product molecular weight 377.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References for AzP3S

References are publications that support the biological activity of the product.

Chatterjee et al (2023) Sulfonylation of RNA 2'-OH groups. ACS Cent.Sci 9 531 PMID: 36968531

If you know of a relevant reference for AzP3S, please let us know.

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Keywords: AzP3S, AzP3S supplier, pyridine, sulfonyl, triazaole, RNA, SHAPE, MAP, Copper, cu, free, click, chemistry, DNA,, and, Protein, Synthesis, 7975, Tocris Bioscience

Citations for AzP3S

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