Azoramide

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Cat.No. 5796 - Azoramide | C15H17ClN2OS | CAS No. 932986-18-0
Description: Unfolded protein response (UPR) modulator
Chemical Name: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Modulator of unfolded protein response (UPR). Protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER calcium retention. Improves liver ER function, glucose homeostasis and glucose-stimulated insulin secretion in mouse obesity models. Orally bioavailable.

Technical Data

M. Wt 308.83
Formula C15H17ClN2OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 932986-18-0
PubChem ID 7518316
InChI Key VYBFWKKCWTXCQX-UHFFFAOYSA-N
Smiles ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.88 100
ethanol 30.88 100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.19 mL 32.38 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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References

References are publications that support the biological activity of the product.

Fu et al (2015) Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci.Transl.Med. 7 292ra98 PMID: 26084805


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Keywords: Azoramide, Azoramide supplier, unfolded, protein, response, UPR, endoplasmic, reticulum, stress, ER, antidiabetic, orally, bioavailable, folding, modulators, PERK, Other, stress/UPR, 5796, Tocris Bioscience

Citations for Azoramide

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