You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 408.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.45 mL||12.24 mL||24.48 mL|
|5 mM||0.49 mL||2.45 mL||4.9 mL|
|10 mM||0.24 mL||1.22 mL||2.45 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References are publications that support the biological activity of the product.
Nylander et al (2012) Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and Ins sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 10 2127 PMID: 22906130
Ni et al (2012) Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2 425 PMID: 22588880
If you know of a relevant reference for AZD 6482, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: AZD 6482, AZD 6482 supplier, AZD6482, PI, 3-kinase, PI3Kβ, inhibitors, inhibits, selective, potent, antitumor, antitumour, antithrombotics, 3-Kinase, Inositol, Lipids, 4839, Tocris Bioscience
Citations for AZD 6482
Citations are publications that use Tocris products.
Currently there are no citations for AZD 6482. Do you know of a great paper that uses AZD 6482 from Tocris? Please let us know.
Reviews for AZD 6482
There are currently no reviews for this product. Be the first to review AZD 6482 and earn rewards!
Have you used AZD 6482?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.