AZD 6482

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Cat.No. 4839 - AZD 6482 | C22H24N4O4 | CAS No. 1173900-33-8
Description: Potent and selective PI 3-Kβ inhibitor
Chemical Name: (-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

AZD 6482 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 408.45
Formula C22H24N4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1173900-33-8
PubChem ID 44137675
InChI Key IRTDIKMSKMREGO-OAHLLOKOSA-N
Smiles OC(C1=C(N[C@@H](C2=CC(C)=CN3C2=NC(N4CCOCC4)=CC3=O)C)C=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 4.08 10
DMSO 40.84 100
ethanol 8.17 20

Preparing Stock Solutions

The following data is based on the product molecular weight 408.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nylander et al (2012) Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 10 2127 PMID: 22906130

Ni et al (2012) Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2 425 PMID: 22588880


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Keywords: AZD6482 PI 3-kinase PI3Kβ inhibitors inhibits selective potent antitumor antitumour antithrombotics PI 3-Kinase

Citations for AZD 6482

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Literature in this Area

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Kinases

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A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Pathways for AZD 6482

Protocols

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