AZ PFKFB3 67

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Cat.No. 5742 - AZ PFKFB3 67 | C26H25N5O3 | CAS No. 1704741-11-6
Description: Potent and selective PFKFB3 inhibitor
Chemical Name: (2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective PFKFB3 inhibitor (IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively).

Technical Data

M. Wt 455.51
Formula C26H25N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1704741-11-6
PubChem ID 91668554
InChI Key NDIKFKQBWGMLCA-DEOSSOPVSA-N
Smiles N#CC1=CN(CC2=C(C)ON=C2C)C3=C1C=C(OC4=CC=C(NC([C@H]5NCCC5)=O)C=C4)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 45.55 100
DMSO 45.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 455.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611 PMID: 25849762


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Citations for AZ PFKFB3 67

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