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Description: Potent and selective PFKFB3 inhibitor
Chemical Name: (2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity: ≥98% (HPLC)
Citations (4)
Literature (3)

Biological Activity for AZ PFKFB3 67

AZ PFKFB3 67 is a potent and selective PFKFB3 inhibitor (IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively).

Compound Libraries for AZ PFKFB3 67

AZ PFKFB3 67 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ PFKFB3 67

M. Wt 455.51
Formula C26H25N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1704741-11-6
PubChem ID 91668554
Smiles N#CC1=CN(CC2=C(C)ON=C2C)C3=C1C=C(OC4=CC=C(NC([C@H]5NCCC5)=O)C=C4)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZ PFKFB3 67

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.55 100
ethanol 45.55 100

Preparing Stock Solutions for AZ PFKFB3 67

The following data is based on the product molecular weight 455.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets for AZ PFKFB3 67

Certificate of Analysis / Product Datasheet
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References for AZ PFKFB3 67

References are publications that support the biological activity of the product.

Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611 PMID: 25849762

If you know of a relevant reference for AZ PFKFB3 67, please let us know.

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Keywords: AZ PFKFB3 67, AZ PFKFB3 67 supplier, AZPFKFB367, PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, inhibitors, inhibits, glycolysis, 5742, Tocris Bioscience

4 Citations for AZ PFKFB3 67

Citations are publications that use Tocris products. Selected citations for AZ PFKFB3 67 include:

Mihaela et al (2022) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nat Metab 4 123-140 PMID: 35102339

Zheng et al (2022) Suppression of myeloid PFKFB3-driven glycolysis protects mice from choroidal neovascularization. Br J Pharmacol 179 5109-5131 PMID: 35830274

Zheng et al (2017) LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. EMBO J 36 3325 PMID: 28963395

Satoshi et al (2021) PFKFB3-dependent glucose metabolism regulates 3T3-L1 adipocyte development. FASEB J 35 e21728 PMID: 34110658

Do you know of a great paper that uses AZ PFKFB3 67 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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