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Description: Potent and selective PFKFB3 inhibitor
Chemical Name: (2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for AZ PFKFB3 26

AZ PFKFB3 26 is a potent and selective PFKFB3 inhibitor (IC50 = 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50 values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.343 μM). Exhibits no significant inhibition of other kinases.

Compound Libraries for AZ PFKFB3 26

AZ PFKFB3 26 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AZ PFKFB3 26

M. Wt 402.49
Formula C24H26N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1704740-52-2
PubChem ID 118735769
Smiles N#CC1=CN(CC(C)C)C2=C1C=C(OC3=CC=C(NC([C@H]4NCCC4)=O)C=C3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZ PFKFB3 26

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.25 100
ethanol 40.25 100

Preparing Stock Solutions for AZ PFKFB3 26

The following data is based on the product molecular weight 402.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.42 mL 24.85 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for AZ PFKFB3 26

References are publications that support the biological activity of the product.

Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611 PMID: 25849762

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Keywords: AZ PFKFB3 26, AZ PFKFB3 26 supplier, AZPFKFB326, phosphofructokinase2, PFKFB3, inhibitors, inhibits, fructose-1,6-bisphosphate, kinase, cancer, 5675, Tocris Bioscience

Citations for AZ PFKFB3 26

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Literature in this Area

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