AZ Dyrk1B 33

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Cat.No. 5632 - AZ Dyrk1B 33 | C19H16N4 | CAS No. 1679330-37-0
Description: Potent and selective Dyrk1B kinase inhibitor
Chemical Name: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 (Cat. No 5232); displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).

Technical Data

M. Wt 300.36
Formula C19H16N4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1679330-37-0
PubChem ID 118735338
InChI Key CZCUSHJQJWKYTD-UHFFFAOYSA-N
Smiles CC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=CN=CC=C42)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 30.04 100
DMSO 30.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 300.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kettle et al (2015) Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J.Med.Chem. 58 2834 PMID: 25738750


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Citations for AZ Dyrk1B 33

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Literature in this Area

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