AZ Dyrk1B 33

Pricing Availability   Qty
Description: Potent and selective Dyrk1B kinase inhibitor
Chemical Name: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for AZ Dyrk1B 33

AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 (Cat. No 5232); displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).

Compound Libraries for AZ Dyrk1B 33

AZ Dyrk1B 33 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ Dyrk1B 33

M. Wt 300.36
Formula C19H16N4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1679330-37-0
PubChem ID 118735338
Smiles CC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=CN=CC=C42)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZ Dyrk1B 33

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 30.04 100
DMSO 30.04 100

Preparing Stock Solutions for AZ Dyrk1B 33

The following data is based on the product molecular weight 300.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References for AZ Dyrk1B 33

References are publications that support the biological activity of the product.

Kettle et al (2015) Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J.Med.Chem. 58 2834 PMID: 25738750

If you know of a relevant reference for AZ Dyrk1B 33, please let us know.

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Citations for AZ Dyrk1B 33

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Literature in this Area

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