AZ 12080282 dihydrochloride

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Cat.No. 4838 - AZ 12080282 dihydrochloride | C23H20N4O2.2HCl
Description: Inhibitor of Hedgehog (Hh) signaling
Chemical Name: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Inhibitor of Hedgehog (Hh) signaling (IC50 <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

AZ 12080282 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 457.35
Formula C23H20N4O2.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 78243727
Smiles CC1=CC=C(C2=NC=CN2)C=C1NC(C3=CC=C(OCC4=CC=CC=N4)C=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 45.73 100
DMSO 45.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 457.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.93 mL 21.87 mL
5 mM 0.44 mL 2.19 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References are publications that support the biological activity of the product.

Yang et al (2012) Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg.Med.Chem.Lett. 22 4907 PMID: 22704236

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