AZ 12080282 dihydrochloride

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Cat.No. 4838 - AZ 12080282 dihydrochloride | C23H20N4O2.2HCl
Description: Inhibitor of Hedgehog (Hh) signaling
Chemical Name: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of Hedgehog (Hh) signaling (IC50 <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

AZ 12080282 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 457.35
Formula C23H20N4O2.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 78243727
InChI Key CPORFOBFIDPDLZ-UHFFFAOYSA-N
Smiles CC1=CC=C(C2=NC=CN2)C=C1NC(C3=CC=C(OCC4=CC=CC=N4)C=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.73 100
water 45.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 457.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.93 mL 21.87 mL
5 mM 0.44 mL 2.19 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yang et al (2012) Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg.Med.Chem.Lett. 22 4907 PMID: 22704236


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Citations for AZ 12080282 dihydrochloride

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for AZ 12080282 dihydrochloride

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