Δ⁷-Dehydrocholesterol Reductase

Δ⁷-Dehydrocholesterol reductase (DHCR) is a membrane-bound enzyme that catalyzes the final step of cholesterol biosynthesis (the reduction of the C7-8 double bond in 7-dehydrocholesterol to form cholesterol), using NADPH as a cofactor. Cholesterol is a vital component in biological membranes and in myelin and is necessary for the synthesis of steroid hormones and bile acids.

DHCR is ubiquitously expressed and its highest concentrations are found in the liver and brain. Autosomal recessive mutations in the DHCR7 gene have been linked to Smith-Lemli-Opitz syndrome, an inherited disease causing multiple congenital abnormalities linked to defects in cholesterol biosynthesis. The human gene encoding this enzyme is localized to 11q12-13.

External sources of pharmacological information for Δ⁷-Dehydrocholesterol Reductase :

• BJP Guide

Literature for Δ⁷-Dehydrocholesterol Reductase

Tocris offers the following scientific literature for Δ⁷-Dehydrocholesterol Reductase to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

• 7-TM Receptors
• Enzymes
• Enzyme-Linked Receptors
• Ion Channels
• Nuclear Receptors
• Transporters

• Chemogenetics
• Epigenetics
• Fluorescent Imaging
• PROTACs
• Signal Transduction
• Stem Cells

• Download PDF
• View all Product Guides & Listings

Δ⁷-Dehydrocholesterol Reductase Gene Data