Δ⁷-Dehydrocholesterol Reductase

Δ⁷-Dehydrocholesterol reductase (DHCR) is a membrane-bound enzyme that catalyzes the final step of cholesterol biosynthesis (the reduction of the C7-8 double bond in 7-dehydrocholesterol to form cholesterol), using NADPH as a cofactor. DHCR is ubiquitously expressed.

Products

Background

Literature (1)

Gene Data

Inhibitors
Cat. No.	Product Name / Activity
1639	AY 9944 dihydrochloride
	Δ⁷-Dehydrocholesterol reductase inhibitor. Also inhibits hedgehog (Hh) signaling

Δ⁷-Dehydrocholesterol reductase (DHCR) is a membrane-bound enzyme that catalyzes the final step of cholesterol biosynthesis (the reduction of the C7-8 double bond in 7-dehydrocholesterol to form cholesterol), using NADPH as a cofactor. Cholesterol is a vital component in biological membranes and in myelin and is necessary for the synthesis of steroid hormones and bile acids.

DHCR is ubiquitously expressed and its highest concentrations are found in the liver and brain. Autosomal recessive mutations in the DHCR7 gene have been linked to Smith-Lemli-Opitz syndrome, an inherited disease causing multiple congenital abnormalities linked to defects in cholesterol biosynthesis. The human gene encoding this enzyme is localized to 11q12-13.

External sources of pharmacological information for Δ⁷-Dehydrocholesterol Reductase :

BJP Guide

Literature for Δ⁷-Dehydrocholesterol Reductase

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