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JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.1||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 409.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.88 mL||24.42 mL||48.84 mL|
|2.5 mM||0.98 mL||4.88 mL||9.77 mL|
|5 mM||0.49 mL||2.44 mL||4.88 mL|
|25 mM||0.1 mL||0.49 mL||0.98 mL|
References are publications that support the biological activity of the product.
Manshouri et al (2011) Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71 3831 PMID: 21512135
Quintás-Cardama et al (2011) Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest.New Drugs 29 818 PMID: 20372971
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Keywords: Atiprimod dihydrochloride, Atiprimod dihydrochloride supplier, JAK2, kinases, inhibitors, inhibits, induces, apoptosis, proapoptotic, janus, activated, STAT3, STAT5, JAK, Kinase, 4580, Tocris Bioscience
Citations for Atiprimod dihydrochloride
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Literature in this Area
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