Atiprimod dihydrochloride

Pricing Availability   Qty
Description: JAK2 inhibitor
Chemical Name: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride
Literature (1)
Pathways (1)

Biological Activity for Atiprimod dihydrochloride

Atiprimod dihydrochloride is a JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.

Technical Data for Atiprimod dihydrochloride

M. Wt 409.52
Formula C22H44N2.2HCl
Storage Desiccate at RT
CAS Number 130065-61-1
PubChem ID 166556

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Atiprimod dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 20.48 50
DMSO 4.1 10 with gentle warming

Preparing Stock Solutions for Atiprimod dihydrochloride

The following data is based on the product molecular weight 409.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.88 mL 24.42 mL 48.84 mL
2.5 mM 0.98 mL 4.88 mL 9.77 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
25 mM 0.1 mL 0.49 mL 0.98 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Atiprimod dihydrochloride

References for Atiprimod dihydrochloride

References are publications that support the biological activity of the product.

Manshouri et al (2011) Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71 3831 PMID: 21512135

Quintás-Cardama et al (2011) Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest.New Drugs 29 818 PMID: 20372971

If you know of a relevant reference for Atiprimod dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all JAK Inhibitors

Keywords: Atiprimod dihydrochloride, Atiprimod dihydrochloride supplier, JAK2, kinases, inhibitors, inhibits, induces, apoptosis, proapoptotic, janus, activated, STAT3, STAT5, JAK, Kinase, 4580, Tocris Bioscience

Citations for Atiprimod dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Atiprimod dihydrochloride. Do you know of a great paper that uses Atiprimod dihydrochloride from Tocris? Please let us know.

Reviews for Atiprimod dihydrochloride

There are currently no reviews for this product. Be the first to review Atiprimod dihydrochloride and earn rewards!

Have you used Atiprimod dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Atiprimod dihydrochloride

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.