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Atiprimod dihydrochloride

Cat. No. 4580 Submit a Review Datasheet / COA / SDS
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Description: JAK2 inhibitor
Chemical Name: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Atiprimod dihydrochloride

Atiprimod dihydrochloride is a JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.

Technical Data for Atiprimod dihydrochloride

M. Wt 409.52
Formula C22H44N2.2HCl
Storage Desiccate at RT
CAS Number 130065-61-1
PubChem ID 166556
InChI Key MOUZYBYTICOTFQ-UHFFFAOYSA-N
Smiles CCCC1(CCC)CCC2(CN(CCCN(CC)CC)CC2)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Atiprimod dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.48 50
DMSO 4.1 10 with gentle warming

Preparing Stock Solutions for Atiprimod dihydrochloride

The following data is based on the product molecular weight 409.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.88 mL 24.42 mL 48.84 mL
2.5 mM 0.98 mL 4.88 mL 9.77 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
25 mM 0.1 mL 0.49 mL 0.98 mL

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Product Datasheets for Atiprimod dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Atiprimod dihydrochloride

References are publications that support the biological activity of the product.

Manshouri et al (2011) Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71 3831 PMID: 21512135

Quintás-Cardama et al (2011) Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest.New Drugs 29 818 PMID: 20372971

If you know of a relevant reference for Atiprimod dihydrochloride, please let us know.

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Keywords: Atiprimod dihydrochloride, Atiprimod dihydrochloride supplier, JAK2, kinases, inhibitors, inhibits, induces, apoptosis, proapoptotic, janus, activated, STAT3, STAT5, JAK, Kinase, 4580, Tocris Bioscience

Citations for Atiprimod dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Atiprimod dihydrochloride. Do you know of a great paper that uses Atiprimod dihydrochloride from Tocris? Please let us know.

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Literature in this Area

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Pathways for Atiprimod dihydrochloride

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.