AT 1015

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Cat.No. 4468 - AT 1015 | C29H33N3O2.HCl | CAS No. 190508-50-0
Description: Long-acting 5-HT2A antagonist
Chemical Name: N-[2-[4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl]ethyl]-1-formyl-4-piperidinecarboxamide hydrochloride
Purity: ≥97% (HPLC)
Literature (6)

Biological Activity

Long-acting 5-HT2A receptor antagonist; inhibits vasoconstriction and blocks platelet aggregation. Prolongs clotting time in a rat model of thrombus formation; ameliorates laurate-induced peripheral vascular lesions in rodents.

Technical Data

M. Wt 492.05
Formula C29H33N3O2.HCl
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 190508-50-0
PubChem ID 9805663
Smiles O=C(C5CCN(C=O)CC5)NCCN(CC3)CC/C3=C1C(C=CC=C4)=C4C=CC2=C\1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 49.2 100
DMSO 49.2 100

Preparing Stock Solutions

The following data is based on the product molecular weight 492.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.16 mL 20.32 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References are publications that support the biological activity of the product.

Rashid et al (2001) Assessment of affinity and dissociation ability of a newly synthesized 5-HT2 antagonist, AT-1015: comparison with other 5-HT2 antagonists. Jpn.J.Pharmacol. 87 189 PMID: 11885967

Kihara et al (2000) AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2A receptors and prevents the laurate-induced peripheral vascular lesions in rats. J.Cardiovasc.Pharmacol. 35 523 PMID: 10774780

Kihara et al (2001) Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time. Eur.J.Pharmacol. 433 157 PMID: 11755147

If you know of a relevant reference for AT 1015, please let us know.

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