AT 1015

Pricing Availability Delivery Time Qty
Cat.No. 4468 - AT 1015 | C29H33N3O2.HCl | CAS No. 190508-50-0
Description: Long-acting 5-HT2A antagonist
Chemical Name: N-[2-[4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl]ethyl]-1-formyl-4-piperidinecarboxamide hydrochloride
Purity: ≥97% (HPLC)

Biological Activity

Long-acting 5-HT2A receptor antagonist; inhibits vasoconstriction and blocks platelet aggregation. Prolongs clotting time in a rat model of thrombus formation; ameliorates laurate-induced peripheral vascular lesions in rodents.

Compound Libraries

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Technical Data

M. Wt 492.05
Formula C29H33N3O2.HCl
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 190508-50-0
PubChem ID 9805663
Smiles O=C(C5CCN(C=O)CC5)NCCN(CC3)CC/C3=C1C(C=CC=C4)=C4C=CC2=C\1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.2 100
water 49.2 100

Preparing Stock Solutions

The following data is based on the product molecular weight 492.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.16 mL 20.32 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Rashid et al (2001) Assessment of affinity and dissociation ability of a newly synthesized 5-HT2 antagonist, AT-1015: comparison with other 5-HT2 antagonists. Jpn.J.Pharmacol. 87 189 PMID: 11885967

Kihara et al (2000) AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2A receptors and prevents the laurate-induced peripheral vascular lesions in rats. J.Cardiovasc.Pharmacol. 35 523 PMID: 10774780

Kihara et al (2001) Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time. Eur.J.Pharmacol. 433 157 PMID: 11755147

If you know of a relevant reference for AT 1015, please let us know.

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Keywords: AT 1015, supplier, AT1015, supplier, serotonin, 5-HT2, receptor, antagonists, vasoconstriction, antithrombotics, antiplatelet, aggregation, 5-HT2A, Receptors, Tocris Bioscience

Citations for AT 1015

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Literature in this Area


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Pathways for AT 1015


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