Home / Enzymes / Kinases / PI 3-kinase / PI 3-kinase Inhibitors / AS 605240

AS 605240

Cat. No. 3578 2 Citations COA / Product Datasheet SDS
Pricing Availability Delivery Time Qty
Cat.No. 3578 - AS 605240 | C12H7N3O2S | CAS No. 648450-29-7
Description: Potent and selective PI 3-kinase γ (PI 3-Kγ) inhibitor
Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8 nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Technical Data

M. Wt 257.27
Formula C12H7N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 648450-29-7
PubChem ID 5289247
InChI Key SQWZFLMPDUSYGV-POHAHGRESA-N
Smiles O=C(/C(S3)=C/C(C=C2)=CC1=C2N=CC=N1)NC3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.26 1mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 257.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.89 mL 19.43 mL 38.87 mL
5 mM 0.78 mL 3.89 mL 7.77 mL
10 mM 0.39 mL 1.94 mL 3.89 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Peng et al (2010) Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice. J.Pharmacol.Exp.Ther. 332 46 PMID: 19828878

Camps et al (2005) Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nature Med. 11 936 PMID:

Wang et al (2009) Phosphoinositide 3-kinase γ inhibitor ameliorates concanavalin A-induced hepatic injury in mice. Biochem.Biophys.Res.Comm. 386 569 PMID:

If you know of a relevant reference for AS 605240, please let us know.

View Related Products by Target

View Related Products by Product Action

View all PI 3-kinase Inhibitors

Keywords: AS 605240, supplier, AS605240, PI3Kgamma, PI3Kγ, PI, 3-kinasegamma, 3-kinaseg, 3-kinaseγ, phosphoinositide, 3, kinases, gamma, γ, Potent, selective, inhibitors, inhibits, inositol, lipids, signalling, signaling, orally, active, ATP-competitive, PI, 3-Kinase, Tocris Bioscience

2 Citations for AS 605240

Citations are publications that use Tocris products. Selected citations for AS 605240 include:

Beauséjour et al (2012) Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis 17 566 PMID: 22402981

Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol 81 832 PMID: 22434859

Do you know of a great paper that uses AS 605240 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pathways for AS 605240

Protocols

TODO: Add Protocols