AS 101

Pricing Availability Delivery Time Qty
Cat.No. 2446 - AS 101 | C2H4Cl3O2Te.NH4 | CAS No. 106566-58-9
Description: Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
Chemical Name: Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate
Datasheet
Citations (1)
Literature

Biological Activity

Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release.

Technical Data

M. Wt 312.05
Formula C2H4Cl3O2Te.NH4
Storage Desiccate at RT
CAS Number 106566-58-9
PubChem ID 24985142
InChI Key QMAYWSOREZFIPD-UHFFFAOYSA-L
Smiles [Cl-].[Cl-].[Cl-].[Te+4].[O-]CC[O-].[H][N+]([H])([H])[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.56 5mM with gentle warming
ethanol 1.56 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 312.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.02 mL 32.05 mL
5 mM 0.64 mL 3.2 mL 6.41 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

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Safety Datasheet

References

References are publications that support the products' biological activity.

Kalechman et al (2004) Inhibition of interleukin-10 by the immunomodulator AS101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis. J.Biol.Chem. 279 24724 PMID: 15001575


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Keywords: Immunomodulators inhibits inhibitors IL-10 synthesis potentiates IL-1alpha IL-2 TNFalpha release TNF-α TNF-alpha Interleukins Tumor Necrosis Factor-α Factor-alpha Cytokines Cytokine NF-κB NF-kappaB Signaling Signalling AS101 Cytokines

1 Citation for AS 101

Citations are publications that use Tocris products. Selected citations for AS 101 include:

Souza-Fonseca-Guimaraes et al (2012) NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis. J Immunol 188 5850 PMID: 22566566


Do you know of a great paper that uses AS 101 from Tocris? If so please let us know.

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