AS 101

Pricing Availability Delivery Time Qty
Cat.No. 2446 - AS 101 | C2H4Cl3O2Te.NH4 | CAS No. 106566-58-9
Description: Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
Chemical Name: Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release.

Technical Data

M. Wt 312.05
Formula C2H4Cl3O2Te.NH4
Storage Desiccate at RT
CAS Number 106566-58-9
PubChem ID 24985142
InChI Key QMAYWSOREZFIPD-UHFFFAOYSA-L
Smiles [Cl-].[Cl-].[Cl-].[Te+4].[O-]CC[O-].[H][N+]([H])([H])[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.56 5mM with gentle warming
ethanol 1.56 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 312.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.02 mL 32.05 mL
5 mM 0.64 mL 3.2 mL 6.41 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Kalechman et al (2004) Inhibition of interleukin-10 by the immunomodulator AS101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis. J.Biol.Chem. 279 24724 PMID: 15001575


If you know of a relevant reference for AS 101, please let us know.

View Related Products by Target

Keywords: AS 101, supplier, Immunomodulators, inhibits, inhibitors, IL-10, synthesis, potentiates, IL-1alpha, IL-2, TNFalpha, release, TNF-α, TNF-alpha, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, AS101, Cytokines, Cytokines, Tocris Bioscience

1 Citation for AS 101

Citations are publications that use Tocris products. Selected citations for AS 101 include:

Souza-Fonseca-Guimaraes et al (2012) NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis. J Immunol 188 5850 PMID: 22566566


Do you know of a great paper that uses AS 101 from Tocris? If so please let us know.

Reviews for AS 101

There are currently no reviews for this product. Be the first to review AS 101 and earn rewards!

Have you used AS 101?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.