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Artesunate is a suppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G2/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Antimalarial.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 384.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.6 mL||13.01 mL||26.01 mL|
|5 mM||0.52 mL||2.6 mL||5.2 mL|
|10 mM||0.26 mL||1.3 mL||2.6 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References are publications that support the biological activity of the product.
Meshnick et al (2002) Artemisinin: mechanisms of action, resistance and toxicity. In.J.Parasitol. 32 1655 PMID: 12435450
Jeong et al (2015) Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. Oncotarget. 6 33046 PMID: 26426994
Liu et al (2018) Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome. Inflammation 41 1546 PMID: 29730819
If you know of a relevant reference for Artesunate, please let us know.
Keywords: Artesunate, Artesunate supplier, malaria, anti-malarial, ROS, inhibitors, inhibits, NLRP3, inflammasome, G2/M, phase, arrest, Inflammasomes, Cell, Cycle, Inhibitors, Antimalarials, 6827, Tocris Bioscience
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