Artesunate

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Cat.No. 6827 - Artesunate | C19H28O8 | CAS No. 88495-63-0
Description: Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
Chemical Name: 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Suppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G2/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Antimalarial.

Technical Data

M. Wt 384.42
Formula C19H28O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 88495-63-0
PubChem ID 6917864
InChI Key FIHJKUPKCHIPAT-AHIGJZGOSA-N
Smiles [H][C@@]12CC[C@H]([C@@]3(CC[C@]4(OO[C@@]13[C@](O[C@H]([C@@H]2C)OC(CCC(O)=O)=O)(O4)[H])C)[H])C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.44 100
ethanol 38.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 384.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13.01 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References

References are publications that support the biological activity of the product.

Meshnick et al (2002) Artemisinin: mechanisms of action, resistance and toxicity. In.J.Parasitol. 32 1655 PMID: 12435450

Jeong et al (2015) Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. Oncotarget. 6 33046 PMID: 26426994

Liu et al (2018) Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome. Inflammation 41 1546 PMID: 29730819


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Keywords: Artesunate, Artesunate supplier, malaria, anti-malarial, ROS, inhibitors, inhibits, NLRP3, inflammasome, G2/M, phase, arrest, Inflammasomes, Cell, Cycle, Inhibitors, Antimalarials, 6827, Tocris Bioscience

Citations for Artesunate

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