Artemisinin

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Cat.No. 2668 - Artemisinin | C15H22O5 | CAS No. 63968-64-9
Description: Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum
Alternative Names: Qinghaosu
Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

Antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.

Compound Libraries

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Technical Data

M. Wt 282.33
Formula C15H22O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 63968-64-9
PubChem ID 68827
InChI Key BLUAFEHZUWYNDE-NNWCWBAJSA-N
Smiles O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.23 100
ethanol 21.17 75

Preparing Stock Solutions

The following data is based on the product molecular weight 282.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Balint (2001) Artemisinin and its derivatives. An important new class of antimalarial agents. Pharmacol.Ther. 90 261 PMID: 11578659

Eckstein-Ludwig et al (2003) Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 957 PMID: 12931192

Wartenberg et al (2003) The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab.Invest. 83 1647 PMID: 14615418


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Keywords: Artemisinin, supplier, Antimalarial, inhibits, inhibitors, P-type, ATPase, PfATP6, P, falciparum, Calcium-ATPase, SERCA, PMCA, Ca2+-ATPase, Ion, Transporters, Pumps, P-Type, V-Type, E-Type, F-Type, ATPases, GTPases, Ca2+, modulators, Signaling, Signalling, Calcium, Qinghaosu, Ca2+-ATPase, Tocris Bioscience

Citations for Artemisinin

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