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Cat.No. 2668 - Artemisinin | C15H22O5 | CAS No. 63968-64-9
Description: Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum
Alternative Names: Qinghaosu
Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
Purity: ≥99% (HPLC)

Biological Activity for Artemisinin

Artemisinin is an antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.

Technical Data for Artemisinin

M. Wt 282.33
Formula C15H22O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 63968-64-9
PubChem ID 68827
Smiles O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Artemisinin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.23 100
ethanol 21.17 75

Preparing Stock Solutions for Artemisinin

The following data is based on the product molecular weight 282.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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References for Artemisinin

References are publications that support the biological activity of the product.

Balint (2001) Artemisinin and its derivatives. An important new class of antimalarial agents. Pharmacol.Ther. 90 261 PMID: 11578659

Eckstein-Ludwig et al (2003) Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 957 PMID: 12931192

Wartenberg et al (2003) The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab.Invest. 83 1647 PMID: 14615418

If you know of a relevant reference for Artemisinin, please let us know.

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