Arcyriaflavin A
Biological Activity
Potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM). Also active against CaM kinase II (IC50 = 25 nM) but displays selectivity over several other kinases in vitro (IC50 values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM).
Compound Libraries
Arcyriaflavin A is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 325.32 |
| Formula | C20H11N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 118458-54-1 |
| PubChem ID | 5327723 |
| InChI Key | KAJXOWFGKYKMMZ-UHFFFAOYSA-N |
| Smiles | O=C1NC(=O)C2=C1C1=C(NC3=CC=CC=C13)C1=C2C2=C(N1)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.53 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 325.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.07 mL | 15.37 mL | 30.74 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.15 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.07 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Slater et al (1999) Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg.Med.Chem. 7 1067 PMID: 10428375
Zhu et al (2003) Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 1231 PMID: 12657252
Sanchez-Martinez et al (2003) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 3835 PMID: 14552791
If you know of a relevant reference for Arcyriaflavin A, please let us know.
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Keywords: Potent CaM Kinase II cdk4 cyclin D1 inhibitors inhibits Antiviral agent anti-HCMV Calmodulin-Activated calmodulin-dependent Protein Kinases Cdk Cyclin-Dependent Ca2+ Binding modulators Calmodulin Calcium Signaling Signalling ArcyriaflavinA Cyclin-dependent Kinase
Citations for Arcyriaflavin A
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