Apicidin

Pricing Availability Delivery Time Qty
Cat.No. 4846 - Apicidin | C34H49N5O6 | CAS No. 183506-66-3
Description: Potent histone deacetylase inhibitor
Chemical Name: Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent histone deacetylase (HDAC) inhibitor (IC50 = 0.7 nM in an enzyme activity assay). Antiangiogenic and anti-invasive; blocks proliferation of human stomach and breast cancer cells. Induces apoptosis and autophagy in human oral squamous carcinoma cells.

Technical Data

M. Wt 623.78
Formula C34H49N5O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 183506-66-3
PubChem ID 44593387
InChI Key JWOGUUIOCYMBPV-VWIQTCEGSA-N
Smiles CON2C1=CC=CC=C1C(C[C@@H](C(N[C@@H]([C@H](C)CC)C3=O)=O)NC([C@H](CCCCCC(CC)=O)NC([C@]4([H])N3CCCC4)=O)=O)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.94 1.5
ethanol 0.94 1.5

Preparing Stock Solutions

The following data is based on the product molecular weight 623.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.6 mL 8.02 mL 16.03 mL
5 mM 0.32 mL 1.6 mL 3.21 mL
10 mM 0.16 mL 0.8 mL 1.6 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Han et al (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 60 6068 PMID: 11085529

Darkin-Rattray et al (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc.Natl.Acad.Sci. 93 13143 PMID: 8917558

Ahn et al (2011) Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells. Oral Oncol. 47 1032 PMID: 21856210

Kim et al (2004) Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials. Biochem.Biophys.Res.Comm. 19 964 PMID: 14985106


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Keywords: potent histone deacetylases HDACs inhibitors inhibits antiangiogenics anti-invasive cancer apoptosis autophagy Histone Deacetylases

Citations for Apicidin

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Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

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Pathways for Apicidin

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