Apicidin

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Cat.No. 4846 - Apicidin | C34H49N5O6 | CAS No. 183506-66-3
Description: Potent histone deacetylase inhibitor
Chemical Name: Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent histone deacetylase (HDAC) inhibitor (IC50 = 0.7 nM in an enzyme activity assay). Antiangiogenic and anti-invasive; blocks proliferation of human stomach and breast cancer cells. Induces apoptosis and autophagy in human oral squamous carcinoma cells.

Technical Data

M. Wt 623.78
Formula C34H49N5O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 183506-66-3
PubChem ID 44593387
InChI Key JWOGUUIOCYMBPV-VWIQTCEGSA-N
Smiles CON2C1=CC=CC=C1C(C[C@@H](C(N[C@@H]([C@H](C)CC)C3=O)=O)NC([C@H](CCCCCC(CC)=O)NC([C@]4([H])N3CCCC4)=O)=O)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.94 1.5
ethanol 0.94 1.5

Preparing Stock Solutions

The following data is based on the product molecular weight 623.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.015 mM 106.88 mL 534.38 mL 1068.75 mL
0.075 mM 21.38 mL 106.88 mL 213.75 mL
0.15 mM 10.69 mL 53.44 mL 106.88 mL
0.75 mM 2.14 mL 10.69 mL 21.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Han et al (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 60 6068 PMID: 11085529

Darkin-Rattray et al (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc.Natl.Acad.Sci. 93 13143 PMID: 8917558

Ahn et al (2011) Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells. Oral Oncol. 47 1032 PMID: 21856210

Kim et al (2004) Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials. Biochem.Biophys.Res.Comm. 19 964 PMID: 14985106


If you know of a relevant reference for Apicidin, please let us know.

View Related Products by Product Action

View all Non-selective Histone Deacetylase Inhibitors

Keywords: Apicidin, Apicidin supplier, potent, histone, deacetylases, HDACs, inhibitors, inhibits, antiangiogenics, anti-invasive, cancer, apoptosis, autophagy, Apoptosis, Inducers, Autophagy, Non-selective, Non-Selective, 4846, Tocris Bioscience

Citations for Apicidin

Citations are publications that use Tocris products.

Currently there are no citations for Apicidin. Do you know of a great paper that uses Apicidin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Rheumatoid Arthritis

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.