Discontinued Product

Apicidin (Cat. No. 4846) has been withdrawn from sale for commercial reasons.
Description: Potent histone deacetylase inhibitor
Chemical Name: Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Apicidin

Potent histone deacetylase (HDAC) inhibitor (IC50 = 0.7 nM in an enzyme activity assay). Antiangiogenic and anti-invasive; blocks proliferation of human stomach and breast cancer cells. Induces apoptosis and autophagy in human oral squamous carcinoma cells.

Technical Data for Apicidin

M. Wt 623.78
Formula C34H49N5O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 183506-66-3
PubChem ID 44593387
Smiles CON2C1=CC=CC=C1C(C[C@@H](C(N[C@@H]([C@H](C)CC)C3=O)=O)NC([C@H](CCCCCC(CC)=O)NC([C@]4([H])N3CCCC4)=O)=O)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Apicidin

Certificate of Analysis / Product Datasheet
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References for Apicidin

References are publications that support the biological activity of the product.

Han et al (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 60 6068 PMID: 11085529

Darkin-Rattray et al (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc.Natl.Acad.Sci. 93 13143 PMID: 8917558

Ahn et al (2011) Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells. Oral Oncol. 47 1032 PMID: 21856210

Kim et al (2004) Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials. Biochem.Biophys.Res.Comm. 19 964 PMID: 14985106

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Keywords: Apicidin, Apicidin supplier, potent, histone, deacetylases, HDACs, inhibitors, inhibits, antiangiogenics, anti-invasive, cancer, apoptosis, autophagy, Apoptosis, Inducers, Autophagy, Non-selective, Non-Selective, 4846, Tocris Bioscience

Citations for Apicidin

Citations are publications that use Tocris products.

Currently there are no citations for Apicidin.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.