AP 20187

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Cat.No. 6297 - AP 20187 | C82H107N5O20 | CAS No. 195514-80-8
Description: Chemical inducer of protein dimerization; active in vivo
Chemical Name: 2,2'-[[2-[(Dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Chemical inducer of dimerization (CID) for use in FKBP fusion protein systems. Induces apoptosis in cells expressing fusion proteins consisting of FKBPF36V and the intracellular domain of the Fas receptor, Fas-associated death domain (FADD) or a caspase. Selective for FKBPF36V-Fas fusion proteins over wild-type FKBP. Induces apoptosis of senescent cells expressing caspase-8-FKBP fusion proteins under the control of an Ink4a promoter. Active in vivo.

Technical Data

M. Wt 1482.77
Formula C82H107N5O20
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 195514-80-8
PubChem ID 78357784
InChI Key NSBGUMKAXUXKGI-BPNHAYRBSA-N
Smiles O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(NCC(CN(C)C)CNC(COC4=CC=CC([C@H](OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)CCC7=CC(OC)=C(OC)C=C7)=C4)=O)=O)=CC=C3)CCC8=CC(OC)=C(OC)C=C8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 148.28 100
ethanol 148.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 1482.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.67 mL 3.37 mL 6.74 mL
5 mM 0.13 mL 0.67 mL 1.35 mL
10 mM 0.07 mL 0.34 mL 0.67 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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References

References are publications that support the biological activity of the product.

Shariat et al (2001) Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer. Cancer Res. 61 2562 PMID: 11289132

Baker et al (2016) Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature 530 184 PMID: 26840489

Ono (2017) Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes. PLoS One 12 e0173176 PMID: 28257518

Jacobs et al (2018) StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nat.Methods 15 523 PMID: 29967496


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Keywords: AP 20187, AP 20187 supplier, AP20187, Chemical, protein, dimerizer, caspases, 9, induces, inducers, apoptosis, FKBPF36V, fusion, FK506-binding, CID, Protein, Dimerizers, 6297, Tocris Bioscience

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