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AP 20187 New
Chemical inducer of dimerization (CID) for use in FKBP fusion protein systems. Induces apoptosis in cells expressing fusion proteins consisting of FKBPF36V and the intracellular domain of the Fas receptor, Fas-associated death domain (FADD) or a caspase. Selective for FKBPF36V-Fas fusion proteins over wild-type FKBP. Induces apoptosis of senescent cells expressing caspase-8-FKBP fusion proteins under the control of an Ink4a promoter. Active in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1482.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.67 mL||3.37 mL||6.74 mL|
|5 mM||0.13 mL||0.67 mL||1.35 mL|
|10 mM||0.07 mL||0.34 mL||0.67 mL|
|50 mM||0.01 mL||0.07 mL||0.13 mL|
References are publications that support the biological activity of the product.
Shariat et al (2001) Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer. Cancer Res. 61 2562 PMID: 11289132
Baker et al (2016) Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature 530 184 PMID: 26840489
Ono (2017) Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes. PLoS One 12 e0173176 PMID: 28257518
Jacobs et al (2018) StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nat.Methods 15 523 PMID: 29967496
If you know of a relevant reference for AP 20187, please let us know.
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Keywords: AP 20187, AP 20187 supplier, AP20187, Chemical, protein, dimerizer, caspases, 9, induces, inducers, apoptosis, FKBPF36V, fusion, FK506-binding, CID, Protein, Dimerizers, 6297, Tocris Bioscience
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