Potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (Cat. No. 4791) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as angiotensin II in vitro (Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Yang et al (2011) Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent. Hypertension 57 956 PMID: 21464395
Coutinho et al (2013) Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system. J.Renin Angiotensin Aldosterone Syst. 15 480 PMID: 23386282
Villela et al (2014) Alamandine: a new member of the angiotensin family. Curr.Opin.Nephrol.Hypertens. 23 130 PMID: 24389733
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Keywords: Angiotensin A, Angiotensin A supplier, Angiotensin, A, II, receptors, potent, endogenous, vasoconstrictor, peptide, AT1, AT2, agonists, Non-selective, AT, Receptors, 5335, Tocris Bioscience
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