Amyloid β-Peptide (12-28) (human)

Pricing Availability Delivery Time Qty
Cat.No. 1894 - Amyloid b-peptide (12-28) (human) | Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys | CAS No. 107015-83-8
Description: Amyloid β-peptide; minimum required for binding to brain proteins
Datasheet
Citations
Literature

Biological Activity

Amyloid β-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo.

Technical Data

M. Wt 1955.2
Formula C89H135N25O25
Sequence VHHQKLVFFAEDVGSNK
Storage Desiccate at -20°C
CAS Number 107015-83-8
PubChem ID 24868224
InChI Key WOMPQPMHRDDZMP-IJBWYZRXSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.70 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1955.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.51 mL 2.56 mL 5.11 mL
5 mM 0.1 mL 0.51 mL 1.02 mL
10 mM 0.05 mL 0.26 mL 0.51 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Flood et al (1994) An amyloid β-protein fragment, A b[12-28], equipotent impairs post-training memory processing when injected into different limbic system structures. Brain Res. 663 271 PMID: 7874511

Freir and Herron (2003) Nicotine enhances the depressive actions of A β 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo. J.Neurophysiol. 89 2917 PMID: 12611941

Ray et al (1998) Binding of amyloid b-protein to intracellular brain proteins in rat and human. Neurochem.Res. 23 1277 PMID: 9804283


If you know of a relevant reference for Amyloid β-Peptide (12-28) (human), please let us know.

View Related Products by Target

Keywords: Amyloid b-peptide (12-28) (human), supplier, Amyloid, β-peptide, beta-peptides, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, Secretase, beta-peptide, (12-28), (human), amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, Peptides, Tocris Bioscience

Citations for Amyloid β-Peptide (12-28) (human)

Citations are publications that use Tocris products.

Currently there are no citations for Amyloid β-Peptide (12-28) (human). Do you know of a great paper that uses Amyloid β-Peptide (12-28) (human) from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Pathways for Amyloid β-Peptide (12-28) (human)

Protocols

TODO: Add Protocols