Amyloid β-Peptide (12-28) (human)
Amyloid β-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.70 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1955.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.51 mL||2.56 mL||5.11 mL|
|5 mM||0.1 mL||0.51 mL||1.02 mL|
|10 mM||0.05 mL||0.26 mL||0.51 mL|
|50 mM||0.01 mL||0.05 mL||0.1 mL|
References are publications that support the biological activity of the product.
Flood et al (1994) An amyloid β-protein fragment, A b[12-28], equipotent impairs post-training memory processing when injected into different limbic system structures. Brain Res. 663 271 PMID: 7874511
Freir and Herron (2003) Nicotine enhances the depressive actions of A β 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo. J.Neurophysiol. 89 2917 PMID: 12611941
Ray et al (1998) Binding of amyloid b-protein to intracellular brain proteins in rat and human. Neurochem.Res. 23 1277 PMID: 9804283
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.