Amyloid β-Peptide (10-20) (human)
Discontinued ProductAmyloid β-Peptide (10-20) (human) (Cat. No. 1892) has been withdrawn from sale for commercial reasons.
Soluble amyloid β-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Miyazaki et al (1993) A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature 362 839 PMID: 8479521
Roher et al (1994) Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A. Biochem.Biophys.Res.Commun. 205 1755 PMID: 7811262
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Literature in this Area
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.