Amyloid β-Peptide (10-20) (human)

Discontinued Product

Unfortunately Amyloid β-Peptide (10-20) (human) (Cat. No. 1892) has been withdrawn from sale for commercial reasons.
Cat.No. 1892 - Amyloid b-peptide (10-20) (human) | Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe | CAS No. 152286-31-2
Description: Amyloid β-peptide; substrate for MMP-2
Alternative Names: β-AP (10-20)

Biological Activity

Soluble amyloid β-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.

Technical Data

M. Wt 1446.67
Formula C71H99N17O16
Storage Desiccate at -20°C
CAS Number 152286-31-2
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1446.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.69 mL 3.46 mL 6.91 mL
5 mM 0.14 mL 0.69 mL 1.38 mL
10 mM 0.07 mL 0.35 mL 0.69 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Miyazaki et al (1993) A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature 362 839 PMID: 8479521

Roher et al (1994) Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A. Biochem.Biophys.Res.Commun. 205 1755 PMID: 7811262

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