Amyloid β-Peptide (10-20) (human)
Discontinued ProductUnfortunately Amyloid β-Peptide (10-20) (human) (Cat. No. 1892) has been withdrawn from sale for commercial reasons.
Soluble amyloid β-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1446.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.69 mL||3.46 mL||6.91 mL|
|5 mM||0.14 mL||0.69 mL||1.38 mL|
|10 mM||0.07 mL||0.35 mL||0.69 mL|
|50 mM||0.01 mL||0.07 mL||0.14 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Miyazaki et al (1993) A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature 362 839 PMID: 8479521
Roher et al (1994) Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A. Biochem.Biophys.Res.Commun. 205 1755 PMID: 7811262
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Keywords: β-Amyloid beta-Amyloid b-amyloid β-peptide beta-peptide fragment substrates gelatinase A type IV collagenase MMP-2 metalloproteinase metalloprotease amyloid precursor protein APP secretase Amyloid beta peptide (10-20) (human) amyloidbeta amyloid b-AP (10-20) Amyloid Beta Peptides
Citations for Amyloid β-Peptide (10-20) (human)
Citations are publications that use Tocris products.
Currently there are no citations for Amyloid β-Peptide (10-20) (human).
Literature in this Area
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.