AMD 3465 hexahydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 4179 - AMD 3465 hexahydrobromide | C24H38N6.6HBr | CAS No. 185991-07-5
Description: Potent and selective CXCR4 antagonist
Chemical Name: N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.

Compound Libraries

AMD 3465 hexahydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 896.07
Formula C24H38N6.6HBr
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 185991-07-5
PubChem ID 9897616
InChI Key ARHBIBDGWDRBJH-UHFFFAOYSA-N
Smiles C1(CN3CCCNCCNCCCNCC3)=CC=C(CNCC2=NC=CC=C2)C=C1.Br.Br.Br.Br.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.4 25
water 44.8 50

Preparing Stock Solutions

The following data is based on the product molecular weight 896.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.12 mL 5.58 mL 11.16 mL
5 mM 0.22 mL 1.12 mL 2.23 mL
10 mM 0.11 mL 0.56 mL 1.12 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Rosenkilde et al (2007) Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J.Biol.Chem. 282 27354 PMID: 17599916

Bodart et al (2009) Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4. Biochem.Pharmacol. 78 993 PMID: 19540208


If you know of a relevant reference for AMD 3465 hexahydrobromide, please let us know.

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1 Citation for AMD 3465 hexahydrobromide

Citations are publications that use Tocris products. Selected citations for AMD 3465 hexahydrobromide include:

Lourenco et al (2015) Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol 194 3463 PMID: 25712213


Do you know of a great paper that uses AMD 3465 hexahydrobromide from Tocris? If so please let us know.

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Literature in this Area

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