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AMD 3465 hexahydrobromide
Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 896.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||2.23 mL||11.16 mL||22.32 mL|
|2.5 mM||0.45 mL||2.23 mL||4.46 mL|
|5 mM||0.22 mL||1.12 mL||2.23 mL|
|25 mM||0.04 mL||0.22 mL||0.45 mL|
References are publications that support the biological activity of the product.
Rosenkilde et al (2007) Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J.Biol.Chem. 282 27354 PMID: 17599916
Bodart et al (2009) Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4. Biochem.Pharmacol. 78 993 PMID: 19540208
If you know of a relevant reference for AMD 3465 hexahydrobromide, please let us know.
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2 Citations for AMD 3465 hexahydrobromide
Citations are publications that use Tocris products. Selected citations for AMD 3465 hexahydrobromide include:
Luo et al (2016) Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain. Mol Pain 12 PMID: 27030717
Lourenco et al (2015) Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol 194 3463 PMID: 25712213
Do you know of a great paper that uses AMD 3465 hexahydrobromide from Tocris? Please let us know.
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