AMD 3465 hexahydrobromide

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Cat.No. 4179 - AMD 3465 hexahydrobromide | C24H38N6.6HBr | CAS No. 185991-07-5
Description: Potent and selective CXCR4 antagonist
Chemical Name: N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (3)

Biological Activity

Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.

Compound Libraries

AMD 3465 hexahydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 896.07
Formula C24H38N6.6HBr
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 185991-07-5
PubChem ID 9897616
InChI Key ARHBIBDGWDRBJH-UHFFFAOYSA-N
Smiles C1(CN3CCCNCCNCCCNCC3)=CC=C(CNCC2=NC=CC=C2)C=C1.Br.Br.Br.Br.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.8 50
DMSO 22.4 25

Preparing Stock Solutions

The following data is based on the product molecular weight 896.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.23 mL 11.16 mL 22.32 mL
2.5 mM 0.45 mL 2.23 mL 4.46 mL
5 mM 0.22 mL 1.12 mL 2.23 mL
25 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Rosenkilde et al (2007) Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J.Biol.Chem. 282 27354 PMID: 17599916

Bodart et al (2009) Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4. Biochem.Pharmacol. 78 993 PMID: 19540208


If you know of a relevant reference for AMD 3465 hexahydrobromide, please let us know.

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Keywords: AMD 3465 hexahydrobromide, AMD 3465 hexahydrobromide supplier, AMD3465, CXCR4, receptor, antagonist, chemokine, chemokines, antagonists, Chemokine, CXC, Receptors, 4179, Tocris Bioscience

2 Citations for AMD 3465 hexahydrobromide

Citations are publications that use Tocris products. Selected citations for AMD 3465 hexahydrobromide include:

Luo et al (2016) Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain. Mol Pain 12 PMID: 27030717

Lourenco et al (2015) Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol 194 3463 PMID: 25712213


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Literature in this Area

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