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Description: DNA polymerase λ and β inhibitor
Chemical Name: (5Z)-5-[[(4-[(2-Methylphenyl)thio]-3-nitrophenyl]methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Biological Activity for AM-TS23
DNA polymerase λ and β inhibitor (IC50 values are 3.9 and 18.2 μM, respectively). Sensitizes human colorectal cancer cells to hydrogen peroxide and temozolomide (Cat. No. 2706) in vitro.
Technical Data for AM-TS23
| M. Wt | 388.48 |
| Formula | C17H12N2O3S3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1489285-17-7 |
| PubChem ID | 72164414 |
| InChI Key | SHKDXDWJERWCHI-DHDCSXOGSA-N |
| Smiles | O=C(/C(S2)=C/C1=CC=C(SC3=CC=CC=C3C)C([N+]([O-])=O)=C1)NC2=S |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AM-TS23
References for AM-TS23
References are publications that support the biological activity of the product.
Strittmatter et al (2014) Expanding the scope of human DNA polymerase λ and β inhibitors. ACS Chem.Biol. 9 282 PMID: 24171552
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Citations for AM-TS23
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.