Discontinued Product

AM-TS23 (Cat. No. 5211) has been withdrawn from sale for commercial reasons.
Description: DNA polymerase λ and β inhibitor
Chemical Name: (5Z)-5-[[(4-[(2-Methylphenyl)thio]-3-nitrophenyl]methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for AM-TS23

DNA polymerase λ and β inhibitor (IC50 values are 3.9 and 18.2 μM, respectively). Sensitizes human colorectal cancer cells to hydrogen peroxide and temozolomide (Cat. No. 2706) in vitro.

Technical Data for AM-TS23

M. Wt 388.48
Formula C17H12N2O3S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1489285-17-7
PubChem ID 72164414
Smiles O=C(/C(S2)=C/C1=CC=C(SC3=CC=CC=C3C)C([N+]([O-])=O)=C1)NC2=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AM-TS23

References are publications that support the biological activity of the product.

Strittmatter et al (2014) Expanding the scope of human DNA polymerase λ and β inhibitors. ACS Chem.Biol. 9 282 PMID: 24171552

View Related Products by Product Action

View all DNA Polymerase Inhibitors

Keywords: AM-TS23, AM-TS23 supplier, DNA, polymerases, inhibitors, lambda, beta, cancer, sensitizers, AM-TS23, β, λ, inhibits, Polymerase, DNA,, RNA, and, Protein, Synthesis, 5211, Tocris Bioscience

Citations for AM-TS23

Citations are publications that use Tocris products.

Currently there are no citations for AM-TS23.

Reviews for AM-TS23

There are currently no reviews for this product. Be the first to review AM-TS23 and earn rewards!

Have you used AM-TS23?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.