AM-TS23

Discontinued Product

AM-TS23 (Cat. No. 5211) has been withdrawn from sale for commercial reasons.
Description: DNA polymerase λ and β inhibitor
Chemical Name: (5Z)-5-[[(4-[(2-Methylphenyl)thio]-3-nitrophenyl]methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for AM-TS23

DNA polymerase λ and β inhibitor (IC50 values are 3.9 and 18.2 μM, respectively). Sensitizes human colorectal cancer cells to hydrogen peroxide and temozolomide (Cat. No. 2706) in vitro.

Technical Data for AM-TS23

M. Wt 388.48
Formula C17H12N2O3S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1489285-17-7
PubChem ID 72164414
InChI Key SHKDXDWJERWCHI-DHDCSXOGSA-N
Smiles O=C(/C(S2)=C/C1=CC=C(SC3=CC=CC=C3C)C([N+]([O-])=O)=C1)NC2=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AM-TS23

References are publications that support the biological activity of the product.

Strittmatter et al (2014) Expanding the scope of human DNA polymerase λ and β inhibitors. ACS Chem.Biol. 9 282 PMID: 24171552

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Citations for AM-TS23

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Currently there are no citations for AM-TS23.

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Literature in this Area

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