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Submit ReviewAM-TS23
Discontinued Product
AM-TS23 (Cat. No. 5211) has been withdrawn from sale for commercial reasons.
Description: DNA polymerase λ and β inhibitor
Chemical Name: (5Z)-5-[[(4-[(2-Methylphenyl)thio]-3-nitrophenyl]methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Biological Activity for AM-TS23
DNA polymerase λ and β inhibitor (IC50 values are 3.9 and 18.2 μM, respectively). Sensitizes human colorectal cancer cells to hydrogen peroxide and temozolomide (Cat. No. 2706) in vitro.
Technical Data for AM-TS23
| M. Wt | 388.48 |
| Formula | C17H12N2O3S3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1489285-17-7 |
| PubChem ID | 72164414 |
| InChI Key | SHKDXDWJERWCHI-DHDCSXOGSA-N |
| Smiles | O=C(/C(S2)=C/C1=CC=C(SC3=CC=CC=C3C)C([N+]([O-])=O)=C1)NC2=S |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AM-TS23
References for AM-TS23
References are publications that support the biological activity of the product.
Strittmatter et al (2014) Expanding the scope of human DNA polymerase λ and β inhibitors. ACS Chem.Biol. 9 282 PMID: 24171552
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Citations for AM-TS23
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