AM 114

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Cat.No. 2564 - AM 114 | C20H21B2NO5 | CAS No. 856849-35-9
Description: 20S proteasome inhibitor
Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one
Purity: ≥97% (HPLC)
Citations (1)
Literature (4)

Biological Activity for AM 114

AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).

Licensing Information

Sold with the permission of Johns Hopkins University

Technical Data for AM 114

M. Wt 377.01
Formula C20H21B2NO5
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 856849-35-9
PubChem ID 11639443
Smiles O=C(/C(CN(C)C3)=C/C2=CC=C(B(O)O)C=C2)/C3=C/C1=CC=C(B(O)O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AM 114

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.77 10

Preparing Stock Solutions for AM 114

The following data is based on the product molecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.52 mL 132.62 mL 265.24 mL
0.5 mM 5.3 mL 26.52 mL 53.05 mL
1 mM 2.65 mL 13.26 mL 26.52 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

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References for AM 114

References are publications that support the biological activity of the product.

Achanta et al (2006) A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol.Pharmacol. 70 426 PMID: 16636137

Achanta et al (2005) Preferential killing of cancer cells with wild-type p53 by boronic chalcones. Proc.Am.Assoc.Cancer Res.Abstr. 46 6162

If you know of a relevant reference for AM 114, please let us know.

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Keywords: AM 114, AM 114 supplier, 20S, proteasome, inhibitors, inhibits, Proteinases, Proteases, AM114, Proteasome, 2564, Tocris Bioscience

1 Citation for AM 114

Citations are publications that use Tocris products. Selected citations for AM 114 include:

Dasgupta et al (2014) Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells. PLoS One 9 e103604 PMID: 25079948

Do you know of a great paper that uses AM 114 from Tocris? Please let us know.

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Literature in this Area

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