AM 114

Pricing Availability Delivery Time Qty
Cat.No. 2564 - AM 114 | C20H21B2NO5 | CAS No. 856849-35-9
Description: 20S proteasome inhibitor
Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one
Purity: ≥97% (HPLC)

Biological Activity

Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).

Licensing Information

Sold with the permission of Johns Hopkins University

Technical Data

M. Wt 377.01
Formula C20H21B2NO5
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 856849-35-9
PubChem ID 11639443
Smiles O=C(/C(CN(C)C3)=C/C2=CC=C(B(O)O)C=C2)/C3=C/C1=CC=C(B(O)O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.77 10

Preparing Stock Solutions

The following data is based on the product molecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.26 mL 26.52 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Achanta et al (2006) A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol.Pharmacol. 70 426 PMID: 16636137

Achanta et al (2005) Preferential killing of cancer cells with wild-type p53 by boronic chalcones. Proc.Am.Assoc.Cancer Res.Abstr. 46 6162 PMID:

If you know of a relevant reference for AM 114, please let us know.

View Related Products by Product Action

View all Proteasome Inhibitors

Keywords: AM 114, supplier, 20S, proteasome, inhibitors, inhibits, Proteinases, Proteases, AM114, Proteasome, Proteasome, Tocris Bioscience

Citations for AM 114

Citations are publications that use Tocris products.

Currently there are no citations for AM 114. Do you know of a great paper that uses AM 114 from Tocris? If so please let us know.

Reviews for AM 114

There are currently no reviews for this product. Be the first to review AM 114 and earn rewards!

Have you used AM 114?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease