AM 114

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Cat.No. 2564 - AM 114 | C20H21B2NO5 | CAS No. 856849-35-9
Description: 20S proteasome inhibitor
Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).

Licensing Information

Sold with the permission of Johns Hopkins University

Technical Data

M. Wt 377.01
Formula C20H21B2NO5
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 856849-35-9
PubChem ID 11639443
InChI Key SRPIKXGUPAKTIZ-OTYYAQKOSA-N
Smiles O=C(/C(CN(C)C3)=C/C2=CC=C(B(O)O)C=C2)/C3=C/C1=CC=C(B(O)O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.77 10

Preparing Stock Solutions

The following data is based on the product molecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.26 mL 26.52 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Achanta et al (2006) A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol.Pharmacol. 70 426 PMID: 16636137

Achanta et al (2005) Preferential killing of cancer cells with wild-type p53 by boronic chalcones. Proc.Am.Assoc.Cancer Res.Abstr. 46 6162 PMID:


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Keywords: AM 114, supplier, 20S, proteasome, inhibitors, inhibits, Proteinases, Proteases, AM114, Proteasome, Tocris Bioscience

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Literature in this Area

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Neurodegeneration

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Pathways for AM 114

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