Discontinued Product

Alsterpaullone (Cat. No. 6400) has been withdrawn from sale for commercial reasons.
Description: Potent CDK1 and CDK2 inhibitor; also inhibits GSK-3β and Lck
Chemical Name: 7,12-Dihydro-9-nitroindolo[3,2-d][1]benzazepin-6(5H)-one
Purity: ≥98% (HPLC)

Biological Activity for Alsterpaullone

Alsterpaullone is a potent CDK1 and 2 inhibitor (IC50 values are 0.035 and 0.08 μM, respectively). Also inhibits GSK-3β and Lck (IC50 values are 0.11 and 0.47 μM, respectively). Induces apoptosis by activation of caspase-9; inhibits growth of cancer cell lines in vitro. Also glucocorticoid receptor inhibitor.

Technical Data for Alsterpaullone

M. Wt 293.28
Formula C16H11N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 237430-03-4
PubChem ID 5005498
Smiles O=C1CC2=C(C3=CC=CC=C3N1)NC4=C2C=C([N+]([O-])=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Alsterpaullone

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