Alfacalcidol

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Cat.No. 4159 - Alfacalcidol | C27H44O2 | CAS No. 41294-56-8
Description: Prodrug of vitamin D3 (Cat. No. 4156)
Alternative Names: 1-Hydroxycholecalciferol
Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Metabolite and prodrug of vitamin D3 (Cat. No. 4156). Improves mechanical bone strength and bone mass; suppresses osteoclastic bone resorption in vivo.

Technical Data

M. Wt 400.64
Formula C27H44O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 41294-56-8
PubChem ID 5282181
InChI Key OFHCOWSQAMBJIW-AVJTYSNKSA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)C)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.06 100
ethanol 40.06 100

Preparing Stock Solutions

The following data is based on the product molecular weight 400.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.48 mL 24.96 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Shiraishi et al (2000) Alfacalcidol inhibits bone resorption and stmulates formation in an ovariectomized rat model of osteoporosis: Distinct actions from estrogen. Journal of Bone and Mineral Research. 15 770


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Keywords: Alfacalcidol, Alfacalcidol supplier, VDR, activators, vitamin, D3, analogue, analog, receptors, 1-Hydroxycholecalciferol, Vitamin, D, Receptors, 4159, Tocris Bioscience

Citations for Alfacalcidol

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