Activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.42 mL||30.85 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the products' biological activity.
Chen et al (2008) An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321 1493 PMID: 18787169
Beretta et al (2010) Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitroglycerin and effects of alda-1. J.Biol.Chem. 285 943 PMID: 19906643
If you know of a relevant reference for Alda 1, please let us know.
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Keywords: Alda 1, supplier, aldehyde, dehydrogenases, activators, aldh2, aldh2*1, aldh2*2, aldh22, aldh21, cardiac, ischemia, Alda1, Aldehyde, Dehydrogenase, Aldehyde, Dehydrogenase, Tocris Bioscience
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