Alda 1

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Cat.No. 4005 - Alda 1 | C15H11Cl2NO3 | CAS No. 349438-38-6
Description: ALDH2 activator; cardioprotective
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.

Compound Libraries

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Technical Data

M. Wt 324.16
Formula C15H11Cl2NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 349438-38-6
PubChem ID 831629
InChI Key NMKJFZCBCIUYHI-UHFFFAOYSA-N
Smiles O=C(C3=C(Cl)C=CC=C3Cl)NCC1=CC(OCO2)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.42 100
ethanol 3.24 10

Preparing Stock Solutions

The following data is based on the product molecular weight 324.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.42 mL 30.85 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2008) An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321 1493 PMID: 18787169

Beretta et al (2010) Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitroglycerin and effects of alda-1. J.Biol.Chem. 285 943 PMID: 19906643


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Keywords: aldehyde dehydrogenases activators aldh2 aldh2*1 aldh2*2 aldh22 aldh21 cardiac ischemia Alda1 Aldehyde Dehydrogenase

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