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Biological Activity for AK 7
AK 7 is a selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.
Compound Libraries for AK 7
Technical Data for AK 7
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AK 7
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AK 7
The following data is based on the product molecular weight 437.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.29 mL||11.43 mL||22.86 mL|
|5 mM||0.46 mL||2.29 mL||4.57 mL|
|10 mM||0.23 mL||1.14 mL||2.29 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References for AK 7
References are publications that support the biological activity of the product.
Chopra et al (2012) The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2 1492 PMID: 23200855
Taylor et al (2011) A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 6 540 PMID: 21370928
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Keywords: AK 7, AK 7 supplier, AK7, SIRT2, sirtuin, inhibitors, inhibits, Huntingdon's, disease, selective, reduces, neuronal, cholesterol, Class, III, HDACs, (Sirtuins), 4754, Tocris Bioscience
1 Citation for AK 7
Citations are publications that use Tocris products. Selected citations for AK 7 include:
Sanjoy et al (2023) SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure. Front Immunol 13 1079962 PMID: 36865524
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Reviews for AK 7
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Literature in this Area
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