AK 7

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Cat.No. 4754 - AK 7 | C19H21BrN2O3S | CAS No. 420831-40-9
Description: Selective SIRT2 inhibitor; brain penetrant
Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

Compound Libraries

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Technical Data

M. Wt 437.35
Formula C19H21BrN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 420831-40-9
PubChem ID 1328033
InChI Key IYAYHZZWYNXHEQ-UHFFFAOYSA-N
Smiles O=C(NC2=CC(Br)=CC=C2)C1=CC(S(N3CCCCCC3)(=O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 437.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.43 mL 22.86 mL
5 mM 0.46 mL 2.29 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Chopra et al (2012) The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2 1492 PMID: 23200855

Taylor et al (2011) A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 6 540 PMID: 21370928


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View all Class III HDAC (Sirtuin) Inhibitors

Keywords: AK 7, AK 7 supplier, AK7, SIRT2, sirtuin, inhibitors, inhibits, Huntingdon's, disease, selective, reduces, neuronal, cholesterol, Class, III, HDACs, (Sirtuins), 4754, Tocris Bioscience

Citations for AK 7

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Literature in this Area

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