Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC50 values are 2.4 and 3 μM respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro. Also weakly inhibits protein kinase C (IC50 = 60 μM).
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117
Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID: 7892601
Plouffe et al (2006) Role of tyrosine kinase receptors in angiotensin II AT2 receptor signaling: Involvement in neurite outgrowth and in p42/p44mapk activation in NG108-15 cells. Endocrinology 147 4646 PMID: 16809450
Yaish et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933 PMID: 3263702
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Literature in this Area
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.