AG 213

Discontinued Product

Unfortunately AG 213 (Cat. No. 0503) has been withdrawn from sale for commercial reasons.
Cat.No. 0503 - AG 213 | C10H8N2O2S | CAS No. 122520-86-9
Description: EGFR/PDGFR-kinase inhibitor
Alternative Names: Tyrphostin AG 213
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenthioamide

Biological Activity

Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC50 values are 2.4 and 3 μM respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro. Also weakly inhibits protein kinase C (IC50 = 60 μM).

Technical Data

M. Wt 220.25
Formula C10H8N2O2S
Storage Desiccate at +4°C
CAS Number 122520-86-9
Smiles OC1=C(O)C=CC(\C=C(C(N)=S)/C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 220.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.54 mL 22.7 mL 45.4 mL
5 mM 0.91 mL 4.54 mL 9.08 mL
10 mM 0.45 mL 2.27 mL 4.54 mL
50 mM 0.09 mL 0.45 mL 0.91 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117

Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID: 7892601

Plouffe et al (2006) Role of tyrosine kinase receptors in angiotensin II AT2 receptor signaling: Involvement in neurite outgrowth and in p42/p44mapk activation in NG108-15 cells. Endocrinology 147 4646 PMID: 16809450

Yaish et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933 PMID: 3263702

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Citations for AG 213

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