Discontinued ProductUnfortunately AG 213 (Cat. No. 0503) has been withdrawn from sale for commercial reasons.
Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC50 values are 2.4 and 3 μM respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro. Also weakly inhibits protein kinase C (IC50 = 60 μM).
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 220.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.54 mL||22.7 mL||45.4 mL|
|5 mM||0.91 mL||4.54 mL||9.08 mL|
|10 mM||0.45 mL||2.27 mL||4.54 mL|
|50 mM||0.09 mL||0.45 mL||0.91 mL|
References are publications that support the products' biological activity.
Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117
Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID: 7892601
Plouffe et al (2006) Role of tyrosine kinase receptors in angiotensin II AT2 receptor signaling: Involvement in neurite outgrowth and in p42/p44mapk activation in NG108-15 cells. Endocrinology 147 4646 PMID: 16809450
Yaish et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933 PMID: 3263702
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Citations for AG 213
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Currently there are no citations for AG 213.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.