AG 18

Pricing Availability Delivery Time Qty
Cat.No. 0493 - AG 18 | C10H6N2O2 | CAS No. 118409-57-7
Description: EGFR/PDGFR-kinase inhibitor
Alternative Names: RG-50810, Tyrphostin A23
Chemical Name: [(3,4-Dihydroxyphenyl)methylene]-propenedinitrile
Datasheet
Citations
Literature

Biological Activity

Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

Technical Data

M. Wt 186.17
Formula C10H6N2O2
Storage Desiccate at +4°C
CAS Number 118409-57-7
PubChem ID 2052
InChI Key VTJXFTPMFYAJJU-UHFFFAOYSA-N
Smiles OC1=C(O)C=C(\C=C(/C#N)C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 186.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.37 mL 26.86 mL 53.71 mL
5 mM 1.07 mL 5.37 mL 10.74 mL
10 mM 0.54 mL 2.69 mL 5.37 mL
50 mM 0.11 mL 0.54 mL 1.07 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gazit et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933 PMID: 3263702

Gazit et al (1989) Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J.Biol.Chem. 264 14503 PMID: 2788167

Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117

Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID: 7892601

Soltoff (2004) Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J.Biol.Chem. 279 10910 PMID: 14688271


If you know of a relevant reference for AG 18, please let us know.

View Related Products by Product Action

View all EGFR Inhibitors

Keywords: EGFR PDGFR kinase inhibitors inhibits Epidermal Growth Factors Receptors ErbB Her Tyrosine Kinases RTKs Platelet Derived AG18 RG50810 RG-50810 Tyrphostin A23 EGFR

Citations for AG 18

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Pathways for AG 18

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