AEBSF

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Cat.No. 5175 - AEBSF | C8H10FNO2S.HCl | CAS No. 30827-99-7
Description: Broad spectrum, irreversible inhibitor of serine proteases
Chemical Name: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Broad spectrum, irreversible inhibitor of serine proteases. Also inhibits NADPH oxidase activation in vitro. Attenuates airway inflammation in a mouse model of airway allergy.

Technical Data

M. Wt 239.69
Formula C8H10FNO2S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 30827-99-7
PubChem ID 186136
InChI Key WRDABNWSWOHGMS-UHFFFAOYSA-N
Smiles NCCC1=CC=C(S(=O)(F)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.97 100
DMSO 23.97 100

Preparing Stock Solutions

The following data is based on the product molecular weight 239.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.17 mL 20.86 mL 41.72 mL
5 mM 0.83 mL 4.17 mL 8.34 mL
10 mM 0.42 mL 2.09 mL 4.17 mL
50 mM 0.08 mL 0.42 mL 0.83 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Diatchuk et al (1997) Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J.Biol.Chem. 272 13292 PMID: 9148950

Saw et al (2012) Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. PLoS ONE 7 e41107 PMID: 22829914


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Keywords: AEBSF, AEBSF supplier, broad, spectrum, irreversible, serine, proteases, inhibitors, inhibits, trypsin, chymotrypsin, plasmin, thrombin, kallikreins, Other, Proteases, 5175, Tocris Bioscience

Citations for AEBSF

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