Broad spectrum, irreversible inhibitor of serine proteases. Also inhibits NADPH oxidase activation in vitro. Attenuates airway inflammation in a mouse model of airway allergy.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 239.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.17 mL||20.86 mL||41.72 mL|
|5 mM||0.83 mL||4.17 mL||8.34 mL|
|10 mM||0.42 mL||2.09 mL||4.17 mL|
|50 mM||0.08 mL||0.42 mL||0.83 mL|
References are publications that support the biological activity of the product.
Diatchuk et al (1997) Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J.Biol.Chem. 272 13292 PMID: 9148950
Saw et al (2012) Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. PLoS ONE 7 e41107 PMID: 22829914
If you know of a relevant reference for AEBSF, please let us know.
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Keywords: AEBSF, AEBSF supplier, broad, spectrum, irreversible, serine, proteases, inhibitors, inhibits, trypsin, chymotrypsin, plasmin, thrombin, kallikreins, Other, Proteases, 5175, Tocris Bioscience
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