ADWX 1

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Cat.No. 4812 - ADWX 1 | Val-Gly-Ile-Asn-Val-Lys-Cys-Lys-His-Ser-Arg-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Thr-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys
Description: Potent and selective KV1.3 channel blocker
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a model for multiple sclerosis.

Technical Data

M. Wt 4071.86
Formula C169H281N57O46S7
Sequence VGINVKCKHSRQCLKPCKDAGMRFGKCTNGKCHCTPK

(Modifications: Disulfide bridge: 7 - 27, 13 - 32, 17 - 34)

Storage Store at -20°C
PubChem ID 90488974
InChI Key KOXLLJFKLFSCAF-UHFFFAOYSA-N
Smiles [H]NC(C(C)C)C(=O)NCC(=O)NC(C(C)CC)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC1CSSCC2NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCSC)NC(=O)CNC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC(=O)C3CSSCC(NC(=O)C(CC4=CNC=N4)NC(=O)C(CSSCC(NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCCN)NC1=O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)N3)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(NC2=O)C(C)O)C(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 4071.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.25 mL 1.23 mL 2.46 mL
5 mM 0.05 mL 0.25 mL 0.49 mL
10 mM 0.02 mL 0.12 mL 0.25 mL
50 mM 0 mL 0.02 mL 0.05 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Han et al (2008) Structural basis of a potent peptide inhibitor designed for KV1.3 channel, a therapeutic target of autoimmune disease. J.Biol.Chem. 283 19058 PMID: 18480054

Li et al (2012) Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model. J.Biol.Chem. 287 29479 PMID: 22761436


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Keywords: ADWX 1, ADWX 1 supplier, ADWX1, KV1.3, potassium, channels, blockers, CD4+, CCR7-, T-cell, autoimmune, encephalomyelitis, multiple, sclerosis., Voltage-Gated, Potassium, Channels, 4812, Tocris Bioscience

Citations for ADWX 1

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