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Submit ReviewACPT-I
Description: Group III mGlu agonist
Chemical Name: (1S,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Biological Activity for ACPT-I
ACPT-I is a agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice.
Licensing Information
Sold with the permission of the CNRS
Technical Data for ACPT-I
| M. Wt | 217.18 |
| Formula | C8H11NO6 |
| Storage | Desiccate at -20°C |
| CAS Number | 194918-76-8 |
| PubChem ID | 4302960 |
| InChI Key | JARNORYOPMINDY-UHFFFAOYSA-N |
| Smiles | N[C@]1([C@](O)=O)C[C@@H]([C@](O)=O)[C@@H]([C@@](O)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ACPT-I
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.17 | 10 | |
| 1.1eq. NaOH | 10.86 | 50 |
Preparing Stock Solutions for ACPT-I
The following data is based on the product molecular weight 217.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 9.21 mL | 46.04 mL | 92.09 mL |
| 2.5 mM | 1.84 mL | 9.21 mL | 18.42 mL |
| 5 mM | 0.92 mL | 4.6 mL | 9.21 mL |
| 25 mM | 0.18 mL | 0.92 mL | 1.84 mL |
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Product Datasheets for ACPT-I
References for ACPT-I
References are publications that support the biological activity of the product.
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676
Chapman et al (2001) Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur.J.Pharmacol. 424 107 PMID: 11476756
De Colle et al (2000) Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor. Eur.J.Pharmacol. 394 17 PMID: 10771029
If you know of a relevant reference for ACPT-I, please let us know.
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Keywords: ACPT-I, ACPT-I supplier, Group, III, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, (Metabotropic), 1111, Tocris Bioscience
1 Citation for ACPT-I
Citations are publications that use Tocris products. Selected citations for ACPT-I include:
Domin et al (2014) Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Proc Natl Acad Sci U S A 26 99 PMID: 24402869
Do you know of a great paper that uses ACPT-I from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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