ACPT-I

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Cat.No. 1111 - ACPT-I | C8H11NO6 | CAS No. 194918-76-8
Description: Group III mGlu agonist
Chemical Name: (1S,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice.

Licensing Information

Sold with the permission of the CNRS

Technical Data

M. Wt 217.18
Formula C8H11NO6
Storage Desiccate at -20°C
CAS Number 194918-76-8
PubChem ID 4302960
InChI Key JARNORYOPMINDY-UHFFFAOYSA-N
Smiles N[C@]1([C@](O)=O)C[C@@H]([C@](O)=O)[C@@H]([C@@](O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.17 10
1.1eq. NaOH 10.86 50

Preparing Stock Solutions

The following data is based on the product molecular weight 217.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 9.21 mL 46.04 mL 92.09 mL
2.5 mM 1.84 mL 9.21 mL 18.42 mL
5 mM 0.92 mL 4.6 mL 9.21 mL
25 mM 0.18 mL 0.92 mL 1.84 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676

Chapman et al (2001) Anticonvulsant activity of a mGlu receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur.J.Pharmacol. 424 107 PMID: 11476756

De Colle et al (2000) Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor. Eur.J.Pharmacol. 394 17 PMID: 10771029


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View all Glutamate (Metabotropic) Group III Receptor Agonists

Keywords: ACPT-I, ACPT-I supplier, Group, III, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, (Metabotropic), 1111, Tocris Bioscience

1 Citation for ACPT-I

Citations are publications that use Tocris products. Selected citations for ACPT-I include:

Domin et al (2014) Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Proc Natl Acad Sci U S A 26 99 PMID: 24402869


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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