ACPT-I

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Cat.No. 1111 - ACPT-I | C8H11NO6 | CAS No. 194918-76-8
Description: Group III mGlu agonist
Chemical Name: (1S,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Datasheet
Citations (1)
Literature

Biological Activity

Agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice.

Licensing Information

Sold with the permission of the CNRS

Technical Data

M. Wt 217.18
Formula C8H11NO6
Storage Desiccate at -20°C
CAS Number 194918-76-8
PubChem ID 4302960
InChI Key JARNORYOPMINDY-UHFFFAOYSA-N
Smiles N[C@]1([C@](O)=O)C[C@@H]([C@](O)=O)[C@@H]([C@@](O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 10.86 50
water 2.17 10

Preparing Stock Solutions

The following data is based on the product molecular weight 217.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.6 mL 23.02 mL 46.04 mL
5 mM 0.92 mL 4.6 mL 9.21 mL
10 mM 0.46 mL 2.3 mL 4.6 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676

Chapman et al (2001) Anticonvulsant activity of a mGlu receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur.J.Pharmacol. 424 107 PMID: 11476756

De Colle et al (2000) Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor. Eur.J.Pharmacol. 394 17 PMID: 10771029


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View Related Products by Product Action

View all Glutamate (Metabotropic) Group III Receptor Agonists

Keywords: ACPT-I, supplier, Group, III, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

1 Citation for ACPT-I

Citations are publications that use Tocris products. Selected citations for ACPT-I include:

Domin et al (2014) Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Proc Natl Acad Sci U S A 26 99 PMID: 24402869


Do you know of a great paper that uses ACPT-I from Tocris? If so please let us know.

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