ACPA

Pricing Availability Delivery Time Qty
Cat.No. 1318 - ACPA | C23H37NO | CAS No. 229021-64-1
Description: Potent, selective CB1 agonist
Alternative Names: Arachidonylcyclopropylamide
Chemical Name: N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Datasheet
Citations (8)
Literature

Biological Activity

Potent and selective CB1 agonist (Ki = 2.2 nM). Displays 325-fold selectivity over CB2 receptors. Active in vivo. Also available in water soluble emulsion (Cat. No. 1781).

Technical Data

M. Wt 343.55
Formula C23H37NO
Storage Store at -20°C
CAS Number 229021-64-1
PubChem ID 5311007
InChI Key GLGAUBPACOBAMV-DOFZRALJSA-N
Smiles O=C(NC1CC1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 343.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.55 mL 29.11 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.46 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hillard et al (1999) Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J.Pharmacol.Exp.Ther. 289 1427 PMID: 10336536

Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884

Patel et al (2001) Cannabinoid CB1 receptor agonists produce cerebellar dysfunction in mice. 2001 Symposium on the Cannabinoids, International PMID:


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Keywords: ACPA, supplier, Potent, selective, CB1, agonists, Cannabinoids, Receptors, cb1r, Arachidonylcyclopropylamide, CB1, Receptors, Tocris Bioscience

8 Citations for ACPA

Citations are publications that use Tocris products. Selected citations for ACPA include:

Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129

Huerta et al (2009) Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog. J Membr Biol 229 91 PMID: 19506935

Morgan et al (2008) Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex. Neural Plast 2008 808564 PMID: 19079598

Newman et al (2007) Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. Eur J Neurosci 25 1619 PMID: 17408433

Han (2017) Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation. Brain Res 1663 132 PMID: 28322749

Sharifi (2017) The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental areamediate morphine-induced memory consolidation impairment. Neuroscience 353 7 PMID: 28412500

Kangarlu-Haghighi et al (2015) The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA. Br J Pharmacol 14 613 PMID: 26648818

Niu et al (2012) Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats. EXCLI J 153 2283 PMID: 22940464


Do you know of a great paper that uses ACPA from Tocris? If so please let us know.

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