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Biological Activity for ACPA
Potent and selective CB1 agonist (Ki = 2.2 nM). Displays 325-fold selectivity over CB2 receptors. Active in vivo.
Water Soluble Emulsion also available.
Technical Data for ACPA
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for ACPA
References are publications that support the biological activity of the product.
Hillard et al (1999) Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J.Pharmacol.Exp.Ther. 289 1427 PMID: 10336536
Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884
Patel et al (2001) Cannabinoid CB1 receptor agonists produce cerebellar dysfunction in mice. 2001 Symposium on the Cannabinoids, International
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Keywords: ACPA, ACPA supplier, Potent, selective, CB1, agonists, Cannabinoids, Receptors, cb1r, Arachidonylcyclopropylamide, 1318, Tocris Bioscience
11 Citations for ACPA
Citations are publications that use Tocris products. Selected citations for ACPA include:
Kangarlu-Haghighi et al (2015) The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA. Br J Pharmacol 14 613 PMID: 26648818
Akerman et al (2013) Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine. J Neurosci 33 14869 PMID: 24027286
Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129
Moghaddam et al (2010) Evaluation of the role of striatal cannabinoid CB1 receptors on movement activity of parkinsonian rats induced by rese. Saudi Pharm J 18 207 PMID: 23960729
Han (2017) Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation. Brain Res 1663 132 PMID: 28322749
Sharifi (2017) The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental areamediate morphine-induced memory consolidation impairment. Neuroscience 353 7 PMID: 28412500
Huerta et al (2009) Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog. J Membr Biol 229 91 PMID: 19506935
Morgan et al (2008) Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex. Neural Plast 2008 808564 PMID: 19079598
Srisai et al (2017) MRAP2 regulates ghrelin receptor signaling and hunger sensing. Nat Commun 8 713 PMID: 28959025
Niu et al (2012) Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats. EXCLI J 153 2283 PMID: 22940464
Newman et al (2007) Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. Eur J Neurosci 25 1619 PMID: 17408433
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.