Acetyl Pepstatin

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Cat.No. 5852 - Acetyl Pepstatin | Ac-Val-Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-Ala-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic-acid | CAS No. 11076-29-2
Description: High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases
Datasheet
Citations
Literature

Biological Activity

High affinity aspartic protease inhibitor. Inhibits HIV-1 protease (Ki = 20 nM at pH 4.7) and HIV-2 protease (Ki = 5 nM at pH 4.7). Antiviral.

Technical Data

M. Wt 643.81
Formula C31H57N5O9
Sequence VVA

(Modifications: Val-1 = N-terminal Ac, Val-2 = Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-(3S,4S)4-amino-3-hydroxy-6-methylheptanoic-acid)

Storage Store at -20°C
CAS Number 11076-29-2
PubChem ID 5481345
InChI Key WKYBEGDEGRCZNF-LBTYKNIQSA-N
Smiles O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(C)=O)C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in PBS

Preparing Stock Solutions

The following data is based on the product molecular weight 643.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.55 mL 7.77 mL 15.53 mL
5 mM 0.31 mL 1.55 mL 3.11 mL
10 mM 0.16 mL 0.78 mL 1.55 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Matúz et al (2012) Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J. 279 3276 PMID: 22804908

Richards et al (1989) Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. FEBS Lett. 247 113 PMID: 2651157

Richards et al (1989) Inhibition of the aspartic proteinase from HIV-2. FEBS Lett. 253 214 PMID: 2668032


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Keywords: High affinity aspartic protease inhibitors HIV-1 proteinases HIV-2 antiviral inhibits Other Proteases

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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