Acetyl Pepstatin

Discontinued Product

Acetyl Pepstatin (Cat. No. 5852) has been withdrawn from sale for commercial reasons.
Description: High affinity HIV-1 and HIV-2 protease inhibitor

Biological Activity for Acetyl Pepstatin

Acetyl Pepstatin is a high affinity aspartic protease inhibitor. Inhibits HIV-1 protease (Ki = 20 nM at pH 4.7) and HIV-2 protease (Ki = 5 nM at pH 4.7). Antiviral.

Technical Data for Acetyl Pepstatin

M. Wt 643.81
Formula C31H57N5O9
Sequence VVA

(Modifications: Val-1 = N-terminal Ac, Val-2 = Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-(3S,4S)4-amino-3-hydroxy-6-methylheptanoic-acid)

Storage Store at -20°C
CAS Number 11076-29-2
PubChem ID 5481345
Smiles O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(C)=O)C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Acetyl Pepstatin

References for Acetyl Pepstatin

References are publications that support the biological activity of the product.

Matúz et al (2012) Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J. 279 3276 PMID: 22804908

Richards et al (1989) Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. FEBS Lett. 247 113 PMID: 2651157

Richards et al (1989) Inhibition of the aspartic proteinase from HIV-2. FEBS Lett. 253 214 PMID: 2668032

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Citations for Acetyl Pepstatin

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