Acetyl Pepstatin

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Cat.No. 5852 - Acetyl Pepstatin | Ac-Val-Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-Ala-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic-acid | CAS No. 11076-29-2
Description: High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity aspartic protease inhibitor. Inhibits HIV-1 protease (Ki = 20 nM at pH 4.7) and HIV-2 protease (Ki = 5 nM at pH 4.7). Antiviral.

Technical Data

M. Wt 643.81
Formula C31H57N5O9
Sequence VVA

(Modifications: Val-1 = N-terminal Ac, Val-2 = Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-(3S,4S)4-amino-3-hydroxy-6-methylheptanoic-acid)

Storage Store at -20°C
CAS Number 11076-29-2
PubChem ID 5481345
InChI Key WKYBEGDEGRCZNF-LBTYKNIQSA-N
Smiles O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(C)=O)C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in PBS

References

References are publications that support the biological activity of the product.

Matúz et al (2012) Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J. 279 3276 PMID: 22804908

Richards et al (1989) Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. FEBS Lett. 247 113 PMID: 2651157

Richards et al (1989) Inhibition of the aspartic proteinase from HIV-2. FEBS Lett. 253 214 PMID: 2668032


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