High affinity aspartic protease inhibitor. Inhibits HIV-1 protease (Ki = 20 nM at pH 4.7) and HIV-2 protease (Ki = 5 nM at pH 4.7). Antiviral.
(Modifications: Val-1 = N-terminal Ac, Val-2 = Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-(3S,4S)4-amino-3-hydroxy-6-methylheptanoic-acid)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in PBS|
Preparing Stock Solutions
The following data is based on the product molecular weight 643.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.55 mL||7.77 mL||15.53 mL|
|5 mM||0.31 mL||1.55 mL||3.11 mL|
|10 mM||0.16 mL||0.78 mL||1.55 mL|
|50 mM||0.03 mL||0.16 mL||0.31 mL|
References are publications that support the products' biological activity.
Matúz et al (2012) Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J. 279 3276 PMID: 22804908
Richards et al (1989) Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. FEBS Lett. 247 113 PMID: 2651157
Richards et al (1989) Inhibition of the aspartic proteinase from HIV-2. FEBS Lett. 253 214 PMID: 2668032
If you know of a relevant reference for Acetyl Pepstatin, please let us know.
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Keywords: Acetyl Pepstatin, supplier, High, affinity, aspartic, protease, inhibitors, HIV-1, proteinases, HIV-2, antiviral, inhibits, Other, Proteases, Antivirals, Other, Proteases, Tocris Bioscience
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