Acetyl-Calpastatin (184-210) (human)

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Description: Selective calpain inhibitor
Purity: ≥95% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Pathways (1)

Biological Activity for Acetyl-Calpastatin (184-210) (human)

Acetyl-Calpastatin (184-210) (human) is a selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data for Acetyl-Calpastatin (184-210) (human)

M. Wt 3177.65
Formula C142H230N36O44S
Sequence DPMSSTYIEELGKREVTIPPKYRELLA

(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 123714-50-1
PubChem ID 90488788
InChI Key ZXJCOYBPXOBJMU-HSQGJUDPSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Acetyl-Calpastatin (184-210) (human)

Solubility Soluble to 5 mg/ml in water

Product Datasheets for Acetyl-Calpastatin (184-210) (human)

Certificate of Analysis / Product Datasheet
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References for Acetyl-Calpastatin (184-210) (human)

References are publications that support the biological activity of the product.

Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866 PMID: 2553724

Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377

Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70


If you know of a relevant reference for Acetyl-Calpastatin (184-210) (human), please let us know.

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Keywords: Acetyl-calpastatin 184-210 (human), Acetyl-calpastatin 184-210 (human) supplier, Selective, calpain, inhibitors, inhibits, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Acetyl-calpastatin184-210, (human), Calpains, 2950, Tocris Bioscience

3 Citations for Acetyl-Calpastatin (184-210) (human)

Citations are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:

Davis et al (2016) Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. Hypertension 1 e86355 PMID: 27158675

Gerónimo-Olvera et al (2017) Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons. Cell Death Dis 8 e2911 PMID: 28661473

Alvarez-Arce (2017) Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization. Int J Cell Biol 2017 1908310 PMID: 29250115


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Reviews for Acetyl-Calpastatin (184-210) (human)

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
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Pathways for Acetyl-Calpastatin (184-210) (human)

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.