Acetyl-Calpastatin (184-210) (human)

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Cat.No. 2950 - Acetyl-calpastatin 184-210 (human) | Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2 | CAS No. 123714-50-1
Description: Selective calpain inhibitor
Datasheet
Citations (3)
Reviews
Pathways (1)

Biological Activity

Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data

M. Wt 3177.65
Formula C142H230N36O44S
Sequence DPMSSTYIEELGKREVTIPPKYRELLA

(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 123714-50-1
PubChem ID 90488788
InChI Key ZXJCOYBPXOBJMU-HSQGJUDPSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 5 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866 PMID: 2553724

Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377

Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70


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Keywords: Acetyl-calpastatin 184-210 (human), Acetyl-calpastatin 184-210 (human) supplier, Selective, calpain, inhibitors, inhibits, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Acetyl-calpastatin184-210, (human), Calpains, 2950, Tocris Bioscience

3 Citations for Acetyl-Calpastatin (184-210) (human)

Citations are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:

Gerónimo-Olvera et al (2017) Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons. Cell Death Dis 8 e2911 PMID: 28661473

Alvarez-Arce (2017) Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization. Int J Cell Biol 2017 1908310 PMID: 29250115

Davis et al (2016) Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. Hypertension 1 e86355 PMID: 27158675


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Pathways for Acetyl-Calpastatin (184-210) (human)

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.