Acetyl-Calpastatin (184-210) (human)

Pricing Availability Delivery Time Qty
Cat.No. 2950 - Acetyl-calpastatin 184-210 (human) | Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2 | CAS No. 123714-50-1
Description: Selective calpain inhibitor
Datasheet
Citations (1)
Pathways

Biological Activity

Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data

M. Wt 3177.65
Formula C142H230N36O44S
Sequence DPMSSTYIEELGKREVTIPPKYRELLA

(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 123714-50-1
PubChem ID 90488788
InChI Key ZXJCOYBPXOBJMU-HSQGJUDPSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3177.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.31 mL 1.57 mL 3.15 mL
5 mM 0.06 mL 0.31 mL 0.63 mL
10 mM 0.03 mL 0.16 mL 0.31 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866 PMID: 2553724

Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377 PMID:

Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70 PMID:


If you know of a relevant reference for Acetyl-Calpastatin (184-210) (human), please let us know.

View Related Products by Product Action

View all Calpain Inhibitors

Keywords: Selective calpain inhibitors inhibits Ca2+Sensitive Protease modulators Calcium-Sensitive Ca2+ Signaling Signalling Proteinases Proteases Acetyl-calpastatin184-210 (human) Calpains

1 Citation for Acetyl-Calpastatin (184-210) (human)

Citations are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:

Davis et al (2016) Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. Hypertension 1 e86355 PMID: 27158675


Do you know of a great paper that uses Acetyl-Calpastatin (184-210) (human) from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pathways for Acetyl-Calpastatin (184-210) (human)

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

TODO: Add Protocols