ABT 594 hydrochloride

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Cat.No. 6576 - ABT 594 hydrochloride | C9H11ClN2O.HCl | CAS No. 203564-54-9
Description: Selective α4β2 nAChR agonist
Alternative Names: Tebanicline
Chemical Name: (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective α4β2 nAChR agonist (EC50 = 140 nM for human α4β2 nAChRs, in vitro). Exhibits >900-fold selectivity for α4β2 nAChRs over other neurotransmitter receptors. Displays analgesic properties in various animal models of pain. Potentiates gabapentin mediated analgesia. Also demonstrates cognitive enhancement effects in rodent model of attention deficit.

Technical Data

M. Wt 235.11
Formula C9H11ClN2O.HCL
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 203564-54-9
PubChem ID 72193963
InChI Key GYVARJONEFSAJB-OGFXRTJISA-N
Smiles ClC1=NC=C(C=C1)OC[C@H]2CCN2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.51 100
DMSO 23.51 100

Preparing Stock Solutions

The following data is based on the product molecular weight 235.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.25 mL 21.27 mL 42.53 mL
5 mM 0.85 mL 4.25 mL 8.51 mL
10 mM 0.43 mL 2.13 mL 4.25 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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References

References are publications that support the biological activity of the product.

Donnelly-Roberts et al (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization. J.Pharmacol.Exp.Ther. 285 777 PMID: 9580626

Lynch et al (2005) ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. Eur.J.Pharmacol. 509 43 PMID: 15713428

Munro et al (2010) Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594. Neuropharmacology 59 208 PMID: 20562022

Mar et al (2017) MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs. Psychopharmacology (Berl) 234 2837 PMID: 28744563


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Citations for ABT 594 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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