ABP 688

Pricing Availability Delivery Time Qty
Cat.No. 5229 - ABP 688 | C15H16N2O | CAS No. 924298-51-1
Description: High affinity human mGlu5 receptor antagonist
Chemical Name: 3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity human mGlu5 receptor antagonist (Ki = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM).

Technical Data

M. Wt 240.3
Formula C15H16N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 924298-51-1
PubChem ID 11481862
InChI Key CNNZLFXCUQLKOB-BMRADRMJSA-N
Smiles CC1=CC=CC(C#CC(CCC2)=C/C2=N/OC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 12.02 50
DMSO 24.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 240.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.16 mL 20.81 mL 41.61 mL
5 mM 0.83 mL 4.16 mL 8.32 mL
10 mM 0.42 mL 2.08 mL 4.16 mL
50 mM 0.08 mL 0.42 mL 0.83 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hintermann et al (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 15 903 PMID: 17110115


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View all Glutamate (Metabotropic) Group I Receptor Antagonists

Keywords: ABP 688, supplier, ABP688, metabotropic, glutamate, receptors, group, I, human, mGlu5, mGluR5, antagonists, antagonism, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience

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