α-Conotoxin PIA

Pricing Availability Delivery Time Qty
Cat.No. 3121 - alpha-Conotoxin PIA | Arg-Asp-Pro-Cys-Cys-Ser-Asn-Pro-Val-Cys-Thr-Val-His-Asn-Pro-Gln-Ile-Cys-NH2 | CAS No. 669050-68-4
Description: Selective antagonist of α6-containing nicotinic receptors
Datasheet
Citations
Literature

Biological Activity

Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).

Licensing Information

Sold under license from University of Utah

Technical Data

M. Wt 1981.3
Formula C79H125N27O25S4
Sequence RDPCCSNPVCTVHNPQIC

(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)

Storage Store at -20°C
CAS Number 669050-68-4
PubChem ID 90488800
InChI Key WINQUAHGULGZED-WAIIABLISA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H](NC(=O)C(NC2=O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(N)=O)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1981.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.5 mL 2.52 mL 5.05 mL
5 mM 0.1 mL 0.5 mL 1.01 mL
10 mM 0.05 mL 0.25 mL 0.5 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445 PMID: 13679412

Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [3H]Dopamine release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231 PMID: 15316087

Chi et al (2005) Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms. 338 1990 PMID:


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Keywords: Selective antagonists a6 α6 alpha6 containing nicotinic receptors Acetylcholine Receptors Non-Selective Subtypes nAChR α-conotoxin alpha-conotoxin PIA a-ConotoxinPIA conotoxins venoms Nicotinic Receptors (Other Subtypes)

Citations for α-Conotoxin PIA

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Literature in this Area

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Pathways for α-Conotoxin PIA

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