α-Conotoxin PIA

Pricing Availability   Qty
Cat.No. 3121 - alpha-Conotoxin PIA | Arg-Asp-Pro-Cys-Cys-Ser-Asn-Pro-Val-Cys-Thr-Val-His-Asn-Pro-Gln-Ile-Cys-NH2 | CAS No. 669050-68-4
Description: Selective antagonist of α6-containing nAChRs
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).

Licensing Information

Sold under license from University of Utah

Technical Data

M. Wt 1981.3
Formula C79H125N27O25S4
Sequence RDPCCSNPVCTVHNPQIC

(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)

Storage Store at -20°C
CAS Number 669050-68-4
PubChem ID 90488800
InChI Key WINQUAHGULGZED-WAIIABLISA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H](NC(=O)C(NC2=O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(N)=O)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445 PMID: 13679412

Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [3H]DA release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231 PMID: 15316087

Chi et al (2005) Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms. 338 1990


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1 Citation for α-Conotoxin PIA

Citations are publications that use Tocris products. Selected citations for α-Conotoxin PIA include:

Garção et al (2013) Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum. Br J Pharmacol 169 1600 PMID: 23638679


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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