Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
Sold under license from University of Utah
(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1981.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.5 mL||2.52 mL||5.05 mL|
|5 mM||0.1 mL||0.5 mL||1.01 mL|
|10 mM||0.05 mL||0.25 mL||0.5 mL|
|50 mM||0.01 mL||0.05 mL||0.1 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445 PMID: 13679412
Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [3H]Dopamine release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231 PMID: 15316087
If you know of a relevant reference for α-Conotoxin PIA, please let us know.
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Keywords: Selective antagonists a6 α6 alpha6 containing nicotinic receptors Acetylcholine Receptors Non-Selective Subtypes nAChR α-conotoxin alpha-conotoxin PIA a-ConotoxinPIA conotoxins venoms Nicotinic Receptors (Other Subtypes)
Citations for α-Conotoxin PIA
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.