You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued Productα-Conotoxin PIA (Cat. No. 3121) has been withdrawn from sale for commercial reasons.
Biological Activity for α-Conotoxin PIA
α-Conotoxin PIA is a selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
Sold under license from University of Utah
Technical Data for α-Conotoxin PIA
(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for α-Conotoxin PIA
References are publications that support the biological activity of the product.
Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445 PMID: 13679412
Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [3H]DA release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231 PMID: 15316087
Chi et al (2005) Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms. 338 1990
View Related Products by Target
View Related Products by Product Action
Keywords: alpha-Conotoxin PIA, alpha-Conotoxin PIA supplier, Selective, antagonists, a6, α6, alpha6, containing, nicotinic, receptors, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, α-conotoxin, alpha-conotoxin, PIA, a-ConotoxinPIA, conotoxins, venoms, Nicotinic, (Other, Subtypes), 3121, Tocris Bioscience
1 Citation for α-Conotoxin PIA
Citations are publications that use Tocris products. Selected citations for α-Conotoxin PIA include:
Garção et al (2013) Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum. Br J Pharmacol 169 1600 PMID: 23638679
Reviews for α-Conotoxin PIA
There are currently no reviews for this product. Be the first to review α-Conotoxin PIA and earn rewards!
Have you used α-Conotoxin PIA?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.