You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for α-Conotoxin MII
α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
Sold under license from the University of Utah.
Technical Data for α-Conotoxin MII
(Modifications: Disulfide bridges: 2-8, 3-16, Cys-16 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for α-Conotoxin MII
|Solubility||Soluble to 1 mg/ml in water|
References for α-Conotoxin MII
References are publications that support the biological activity of the product.
Cartier et al (1996) A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J.Biol.Chem. 271 7522 PMID: 8631783
Harvey et al (1997) Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors. Mol.Pharmacol. 51 336 PMID: 9203640
McIntosh et al (2000) Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function. Eur.J.Pharmacol. 393 205 PMID: 10771014
David et al (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur.J.Neurosci. 31 978 PMID: 20377613
If you know of a relevant reference for α-Conotoxin MII, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: alpha-Conotoxin MII, alpha-Conotoxin MII supplier, Potent, α3β2, alpha3beta2, a3b2, b3, β3, beta3, subunit, selective, nicotinic, antagonist, Acetylcholine, ACh, Receptors, Non-Selective, Subtypes, nAChR, α-conotoxin, alpha-conotoxin, MII, a-ConotoxinMII, venoms, Nicotinic, (Other, Subtypes), 1340, Tocris Bioscience
1 Citation for α-Conotoxin MII
Citations are publications that use Tocris products. Selected citations for α-Conotoxin MII include:
Krais et al (2011) CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. Carcinogenesis 32 1388 PMID: 21586512
Do you know of a great paper that uses α-Conotoxin MII from Tocris? Please let us know.
Reviews for α-Conotoxin MII
There are currently no reviews for this product. Be the first to review α-Conotoxin MII and earn rewards!
Have you used α-Conotoxin MII?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.